2. Gene
  3. JCAD - junctional cadherin 5 associated Gene

JCAD - junctional cadherin 5 associated Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：连接钙粘蛋白 5 相关

种属: Homo sapiens

同用名: KIAA1462

基因 ID: 57608 | 基因类型: protein coding

关于 JCAD

Cytogenetic location: 10p11.23 Genomic coordinates (GRCh38): 10:30,012,803-30,115,494 (from NCBI)

This gene has 3 transcripts (splice variants) and 124 orthologues. Broad expression in fat (RPKM 28.1), lung (RPKM 20.0) and 17 other tissues.

功能概要

该基因编码内皮细胞间连接蛋白。该基因中自然发生的突变与冠状动脉疾病、迟发性阿尔茨海默病和肺气肿分布有关。[RefSeq 提供，2017 年 3 月]

This gene encodes an endothelial cell-to-cell junction protein. Naturally occurring mutations in this gene are associated with coronary artery disease, late onset alzheimer disease, and emphysema distribution. [provided by RefSeq, Mar 2017]

JCAD 基因产物(4)

mRNA Protein Name
NM_001350001.2 NP_001336930.1 junctional cadherin 5-associated protein isoform 2
NM_001350021.2 NP_001336950.1 junctional cadherin 5-associated protein isoform 2
NM_001350022.2 NP_001336951.1 junctional cadherin 5-associated protein isoform 1
NM_020848.4 NP_065899.1 junctional cadherin 5-associated protein isoform 1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
28705794 GOA
involved in positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
28705794 GOA
involved in positive regulation of cell migration involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
28705794 GOA
involved in positive regulation of vascular endothelial growth factor signaling pathway IMP
IMP: 通过突变表型推断
28705794 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in adherens junction IDA
IDA: 通过直接分析推断
28705794 GOA
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
28705794 GOA
located in ruffle membrane IDA
IDA: 通过直接分析推断
28705794 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

JCAD 蛋白结构

JCAD

JCAD: Junctional protein associated with coronary artery disease (1 - 1348)

  • 0
  • 300
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  • 1359 a.a.
蛋白主名 其他名称

junctional cadherin 5-associated protein

junctional protein associated with coronary artery disease

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07032 JCAD Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris JCAD VGNC VGNC:42183
Bos taurus JCAD VGNC VGNC:56189
Mus musculus JCAD MGD MGI:2685174
Felis catus JCAD VGNC VGNC:63003
Rattus norvegicus JCAD RGD RGD:1562037
Macaca mulatta JCAD VGNC VGNC:73937
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