2. Gene
  3. DPP10 - dipeptidyl peptidase like 10 Gene

DPP10 - dipeptidyl peptidase like 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二肽基肽酶样 10

种属: Homo sapiens

同用名: DPL2; DPPY; DPRP3; DPRP-3

基因 ID: 57628 | 基因类型: protein coding

关于 DPP10

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:114,442,641-115,845,780 (from NCBI)

This gene has 13 transcripts (splice variants), 272 orthologues and 6 paralogues. Biased expression in brain (RPKM 7.5), adrenal (RPKM 2.9) and 2 other tissues.

功能概要

该基因编码一种单程 II 型膜蛋白，它是丝氨酸蛋白酶家族 SC 中 S9B 家族的成员。这种蛋白质没有可检测的蛋白酶活性，很可能是由于不存在通常存在于丝氨酸蛋白酶催化结构域中的保守丝氨酸残基。然而，它确实结合了特定的电压门控钾通道并改变了它们的表达和生物物理特性。该基因的突变与哮喘有关。已经表征了编码不同亚型的替代转录剪接变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a single-pass type II membrane protein that is a member of the S9B family in clan SC of the serine proteases. This protein has no detectable Protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Mutations in this gene have been associated with asthma. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

DPP10 基因产物(18)

mRNA Protein Name
NM_001004360.5 NP_001004360.3 inactive dipeptidyl peptidase 10 isoform short
NM_001178034.1 NP_001171505.1 inactive dipeptidyl peptidase 10 isoform c
NM_001178036.3 NP_001171507.2 inactive dipeptidyl peptidase 10 isoform a
NM_001178037.3 NP_001171508.2 inactive dipeptidyl peptidase 10 isoform b
NM_001321905.3 NP_001308834.2 inactive dipeptidyl peptidase 10 isoform d
NM_001321906.2 NP_001308835.2 inactive dipeptidyl peptidase 10 isoform short
NM_001321907.3 NP_001308836.2 inactive dipeptidyl peptidase 10 isoform e
NM_001321908.3 NP_001308837.2 inactive dipeptidyl peptidase 10 isoform f
NM_001321909.3 NP_001308838.2 inactive dipeptidyl peptidase 10 isoform g
NM_001321910.3 NP_001308839.2 inactive dipeptidyl peptidase 10 isoform a
NM_001321911.3 NP_001308840.2 inactive dipeptidyl peptidase 10 isoform a
NM_001321912.3 NP_001308841.2 inactive dipeptidyl peptidase 10 isoform h
NM_001321913.3 NP_001308842.2 inactive dipeptidyl peptidase 10 isoform i
NM_001321914.2 NP_001308843.2 inactive dipeptidyl peptidase 10 isoform i
NM_001399849.1 NP_001386778.1 inactive dipeptidyl peptidase 10 isoform a
NM_001399850.1 NP_001386779.1 inactive dipeptidyl peptidase 10 isoform i
NM_001399851.1 NP_001386780.1 inactive dipeptidyl peptidase 10 isoform j
NM_020868.6 NP_065919.3 inactive dipeptidyl peptidase 10 isoform long

DPP10 蛋白结构

DPPIV_N

DPPIV_N: Dipeptidyl peptidase IV (DPP IV) N-terminal region (133 - 499)

Peptidase_S9

Peptidase_S9: Prolyl oligopeptidase family (581 - 783)

  • 0
  • 200
  • 400
  • 600
  • 796 a.a.
蛋白主名 其他名称

inactive dipeptidyl peptidase 10

DPP X

重组 DPP10 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75281 DPP10 Protein, Human (HEK293, His) Q8N608-1 (L56-E796) ≥95%

关联疾病

疾病名称 别名
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Near-Fatal Asthma
Childhood-Onset Asthma

Childhood Asthma

Asthma Childhood
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03961 DPP10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DPP10 VGNC VGNC:61602
Bos taurus DPP10 VGNC VGNC:28186
Mus musculus DPP10 MGD MGI:2442409
Canis familiaris DPP10 VGNC VGNC:40072
Rattus norvegicus DPP10 RGD RGD:1306427
Macaca mulatta DPP10 VGNC VGNC:71873
Others DPP10 NCBI
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