1. Gene
  2. LRRC4C - leucine rich repeat containing 4C Gene

LRRC4C - leucine rich repeat containing 4C Gene

中文名称:含富含亮氨酸重复序列 4C

种属: Homo sapiens

同用名: NGL1; NGL-1

基因 ID: 57689 | 基因类型: protein coding

关于 LRRC4C

Cytogenetic location: 11p12 Genomic coordinates (GRCh38): 11:40,114,199-41,459,652 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues and 22 paralogues. Biased expression in brain (RPKM 5.3), adrenal (RPKM 0.7) and 1 other tissue.

功能概要

NGL1 是 netrin G1 (NTNG1;MIM 608818) 的特异性结合伙伴,netrin G1 是轴突引导分子的 netrin 家族成员 (Lin 等人,2003 [PubMed 14595443]) 。[OMIM 提供,2008 年 3 月]

NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]

LRRC4C 基因产物(2)

mRNA Protein Name
NM_001258419.2 NP_001245348.1 leucine-rich repeat-containing protein 4C precursor
NM_020929.3 NP_065980.1 leucine-rich repeat-containing protein 4C precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cell adhesion molecule binding IPI
IPI: 通过物理相互作用推断
23986473 GOA
enables cell-cell adhesion mediator activity IGI
IGI: 通过遗传相互作用推断
23986473 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14595443 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of axonogenesis IDA
IDA: 通过直接分析推断
14595443 GOA
involved in synaptic membrane adhesion IGI
IGI: 通过遗传相互作用推断
23986473 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
14595443 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LRRC4C 蛋白结构

LRR_5

LRR_5: Leucine rich repeats (6 copies) (90 - 212)

LRR_1

LRR_1: Leucine Rich Repeat (220 - 242)

LRR_8

LRR_8: Leucine rich repeat (244 - 301)

I-set

I-set: Immunoglobulin I-set domain (354 - 443)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 640 a.a.
蛋白主名 其他名称

leucine-rich repeat-containing protein 4C

netrin-G1 ligand

LRRC4C 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LRRC4C Q9HCJ2 PGAP2 Homo sapiens Q9UHJ9-5 32296183
种属内
LRRC4C Q9HCJ2 NTNG1 Homo sapiens Q9Y2I2
SPR
21946559
种属内
LRRC4C Q9HCJ2 NTNG2 Homo sapiens Q96CW9
SPR
21946559
种属内
LRRC4C Q9HCJ2 DOLK Homo sapiens Q9UPQ8 32296183
种属内
LRRC4C Q9HCJ2 DOLK Homo sapiens Q9UPQ8 32296183
种属内
LRRC4C Q9HCJ2 DOLK Homo sapiens Q9UPQ8 33961781
种属内
LRRC4C Q9HCJ2 DOLK Homo sapiens Q9UPQ8 28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LRRC4C 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77102 NGL-1/LRRC4C Protein, Human (HEK293, His) Q9HCJ2/NP_001245348.1 (Q45-K527) ≥95%

关联疾病

疾病名称 别名
Developmental And Epileptic Encephalopathy 2

Epileptic Encephalopathy, Early Infantile, 2

DEE2

Eiee2

Issx2

Developmental And Epileptic Encephalopathy, 2

Infantile Spasm Syndrome, X-Linked 2

Early Infantile Epileptic Encephalopathy 2

X-Linked Infantile Spasm Syndrome 2

Atypical Rett Syndrome Cdkl5-Related

Atypical Rett Syndrome Hanefeld Variant

Infantile Spasm Syndrome X-Linked 2

Rett Syndrome Early-Onset Seizure Variant

Rett Syndrome Variant With Infantile Spasms

Encephalopathy, Epileptic, Early Infantile, Type 2

Colon Mucinous Adenocarcinoma

Colonic Mucinous Adenocarcinoma

Mucinous Adenocarcinoma Of The Colon

Developmental And Epileptic Encephalopathy 1

Epileptic Encephalopathy, Early Infantile, 1

Infantile Epileptic-Dyskinetic Encephalopathy

DEE1

Eiee1

Issx1

Xmesid

X-Linked Infantile Spasm Syndrome 1

X-Linked Infantile Spasm Syndrome

X-Linked Spasticity-Intellectual Disability-Epilepsy Syndrome

Developmental And Epileptic Encephalopathy, 1

Infantile Epileptic Dyskinetic Encephalopathy

Infantile Spasm Syndrome, X-Linked 1

West Syndrome, X-Linked

Ohtahara Syndrome, X-Linked

Early Infantile Epileptic Encephalopathy 1

Early Infantile Epileptic Encephalopathy-1

Issx

X-Linked Ohtahara Syndrome

X-Linked West Syndrome

Infantile Spasm Syndrome X-Linked 1

Myoclonic Epilepsy X-Linked With Intellectual Disability And Spasticity

Ohtahara Syndrome X-Linked

West Syndrome X-Linked

Encephalopathy, Epileptic, Early Infantile, Type 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LRRC4C VGNC VGNC:74391
Canis familiaris LRRC4C VGNC VGNC:42803
Bos taurus LRRC4C VGNC VGNC:31020
Rattus norvegicus LRRC4C RGD RGD:1311013
Felis catus LRRC4C VGNC VGNC:63304
Mus musculus LRRC4C MGD MGI:2442636
Others LRRC4C NCBI