NGL-1/LRRC4C 蛋白, Human (HEK293, His)

NGL-1/LRRC4C protein may promote neurite outgrowth of thalamic neurons, suggesting a role in neurodevelopment. The specific molecular mechanisms and their interactions with NTNG1 and WHRN require further study. NGL-1/LRRC4C Protein, Human (HEK293, His) is the recombinant human-derived NGL-1/LRRC4C protein, expressed by HEK293 , with C-His labeled tag.

NGL-1/LRRC4C 蛋白可能促进丘脑神经元发育中的神经突生长，表明其在促进复杂的神经发育过程中发挥作用。其对神经突生长影响的具体分子机制仍有待充分阐明，这促使进一步研究其在这方面的功能意义。值得注意的是，NGL-1/LRRC4C 与 NTNG1 和 WHRN 相互作用，这意味着潜在的分子伙伴关系可能有助于其在神经突延伸中的调节作用。NGL-1/LRRC4C 参与促进神经突生长的提议强调了其在塑造发育中丘脑神经元的连接和生长方面的潜在重要性。深入研究对于揭示 NGL-1/LRRC4C 调节神经突生长的精确分子途径并了解其在神经发育中的更广泛影响至关重要。

Measured by its binding ability in a functional ELISA. Immobilized Human NGL-1 at 2 μg/mL (100 μL/well) can bind Human NTNG1(HY-P71176). The KD for this effect is 3.325 nM.

Human

HEK293

C-10*His

Q9HCJ2/NP_001245348.1 (Q45-K527)

57689  [NCBI]

QTCPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHNPWNCNCDILWLSWWIKDMAPSNTACCARCNTPPNLKGRYIGELDQNYFTCYAPVIVEPPADLNVTEGMAAELKCRASTSLTSVSWITPNGTVMTHGAYKVRIAVLSDGTLNFTNVTVQDTGMYTCMVSNSVGNTTASATLNVTAATTTPFSYFSTVTVETMEPSQDEARTTDNNVGPTPVVDWETTNVTTSLTPQSTRSTEKTFTIPVTDINSGIPGIDEVMKTTK

Approximately 90-115 kDa due to the glycosylation.

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.