GAS6 蛋白, Human (630a.a, HEK293, His)

The GAS6 protein is a ligand for AXL, TYRO3 and MER receptors and affects a variety of cellular processes. GAS6/AXL signaling promotes endothelial cell survival, aids cytokine signaling in natural killer cell development, supports liver regeneration, affects gonadotropin-releasing hormone neuron survival and migration, modulates platelet activation, and regulates thrombotic responses. GAS6 Protein, Human (630a.a, HEK293, His) is the recombinant human-derived GAS6 protein, expressed by HEK293 , with C-His labeled tag. The total length of GAS6 Protein, Human (630a.a, HEK293, His) is 630 a.a., with molecular weight of 71-75 kDa.

GAS6 是酪氨酸蛋白激酶受体 AXL、TYRO3 和 MER 的配体，参与多种细胞过程，包括细胞生长、存活、粘附和迁移。GAS6/AXL 信号传导通过防止细胞凋亡，有助于酸性条件下内皮细胞的存活，促进人类自然杀伤细胞发育过程中的最佳细胞因子信号传导，在肝再生中发挥作用，影响促性腺激素释放激素神经元的存活和迁移，调节血小板活化，并调节血栓反应。此外，在微生物感染中，GAS6 可以充当病毒包膜磷脂酰丝氨酸和 TAM 受体酪氨酸激酶 Axl 之间的桥梁，通过凋亡拟态促进病毒进入。这种独特的功能延伸到它参与多种病毒的进入过程，包括登革热、痘苗病毒、埃博拉病毒和马尔堡病毒，突显了 GAS6 在细胞和感染环境中的多方面作用。

1. Immobilized Human GAS6, His Tag at 5 μg/mL (100 μl/well) on the plate. Dose response curve for Anti-GAS6 Antibody, hFc Tag with the EC₅₀ of ≤12.3 ng/mL determined by ELISA.
2. Immobilized Human GAS6, His Tag at 5 μg/mL (100 μl/well) on the plate. Dose response curve for Human Axl, hFc Tag with the EC₅₀ of <7.5 ng/mL determined by ELISA.

Human

HEK293

C-His

Q14393-2 (A49-A678)

2621  [NCBI]

71-75 kDa

Greater than 95% as determined by Tris-Bis PAGE.

溶液

Supplied as 0.22 μm filtered solution in 20 mM Tris, 500 mM NaCl (pH 8.5).

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.