2. Gene
  3. GAS6 - growth arrest specific 6 Gene

GAS6 - growth arrest specific 6 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：生长停滞特异性 6

种属: Homo sapiens

同用名: AXSF; AXLLG

基因 ID: 2621 | 基因类型: protein coding

关于 GAS6

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:113,820,549-113,864,076 (from NCBI)

This gene has 5 transcripts (splice variants), 142 orthologues and 3 paralogues. Ubiquitous expression in lung (RPKM 64.9), endometrium (RPKM 57.7) and 24 other tissues.

功能概要

该基因编码一种含γ-羧基谷氨酸 (Gla) 的蛋白质，被认为参与刺激细胞增殖。该基因在许多癌症中经常过度表达，并被认为是不良预后标志物。蛋白质水平升高还与多种疾病状态相关，包括静脉血栓栓塞性疾病、系统性红斑狼疮、慢性肾衰竭和先兆子痫。[RefSeq 提供，2014 年 8 月]

This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

GAS6 基因产物(1)

mRNA Protein Name
NM_000820.4 NP_000811.1 growth arrest-specific protein 6 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
IDA: 通过直接分析推断
16723520 GOA
enables phosphatidylserine binding IDA
IDA: 通过直接分析推断
21501828 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16362042 GOA
enables protein-macromolecule adaptor activity IDA
IDA: 通过直接分析推断
21501828 GOA
enables receptor ligand activity IDA
IDA: 通过直接分析推断
15184064 GOA
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
7634325 GOA
enables signaling receptor binding IDA
IDA: 通过直接分析推断
16359517 GOA
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
7854420 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell chemotaxis IDA
IDA: 通过直接分析推断
19922767 GOA
involved in apoptotic cell clearance IDA
IDA: 通过直接分析推断
21501828 GOA
involved in calcium ion transmembrane transport IDA
IDA: 通过直接分析推断
18395422 GOA
involved in cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
20103767 GOA
involved in cellular response to interferon-alpha IDA
IDA: 通过直接分析推断
19657094 GOA
involved in cellular response to vitamin K IDA
IDA: 通过直接分析推断
16359517 GOA
involved in cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
16359517 GOA
involved in dendritic cell differentiation IEP
IEP: 通过表达模式推断
19657094 GOA
involved in fusion of virus membrane with host plasma membrane IDA
IDA: 通过直接分析推断
21501828 GOA
involved in hematopoietic stem cell migration to bone marrow IDA
IDA: 通过直接分析推断
19922767 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
18680538 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
19922767 GOA
involved in negative regulation of biomineral tissue development IDA
IDA: 通过直接分析推断
20048160 GOA
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
16723520 GOA
involved in negative regulation of dendritic cell apoptotic process IDA
IDA: 通过直接分析推断
19657094 GOA
involved in negative regulation of endothelial cell apoptotic process IDA
IDA: 通过直接分析推断
16359517 GOA
involved in negative regulation of fibroblast apoptotic process IDA
IDA: 通过直接分析推断
16359517 GOA
involved in negative regulation of interleukin-1 production IDA
IDA: 通过直接分析推断
20103767 GOA
involved in negative regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
19657094 GOA
involved in negative regulation of oligodendrocyte apoptotic process IDA
IDA: 通过直接分析推断
16723520 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
19657094 GOA
involved in negative regulation of tumor necrosis factor-mediated signaling pathway IDA
IDA: 通过直接分析推断
19657094 GOA
involved in negative regulation of type II interferon production IDA
IDA: 通过直接分析推断
18840707 GOA
involved in phagocytosis IDA
IDA: 通过直接分析推断
21501828 GOA
acts upstream of or within positive regulation of ERK1 and ERK2 cascade IDA
IDA: 通过直接分析推断
15184064 GOA
involved in positive regulation of cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
18840707 GOA
involved in positive regulation of dendritic cell chemotaxis IDA
IDA: 通过直接分析推断
19657094 GOA
acts upstream of or within positive regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
15184064 GOA
involved in positive regulation of fibroblast proliferation IDA
IDA: 通过直接分析推断
7854420 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
19657094 GOA
involved in positive regulation of natural killer cell differentiation IDA
IDA: 通过直接分析推断
18840707 GOA
involved in positive regulation of phagocytosis IDA
IDA: 通过直接分析推断
18395422 GOA
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
16359517 GOA
involved in positive regulation of protein export from nucleus IDA
IDA: 通过直接分析推断
18680538 GOA
involved in positive regulation of protein kinase activity IDA
IDA: 通过直接分析推断
7854420 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: 通过直接分析推断
7854420 GOA
involved in protein localization to plasma membrane IDA
IDA: 通过直接分析推断
16359517 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
16359517 GOA
involved in receptor-mediated virion attachment to host cell IDA
IDA: 通过直接分析推断
21501828 GOA
involved in signal transduction IDA
IDA: 通过直接分析推断
7854420 GOA
involved in symbiont entry into host cell IDA
IDA: 通过直接分析推断
21501828 GOA
involved in viral genome replication IDA
IDA: 通过直接分析推断
21501828 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
18395422 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
8336730 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GAS6 蛋白结构

Gla

Gla: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (53 - 94)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (160 - 195)

EGF_CA

EGF_CA: Calcium-binding EGF domain (197 - 236)

EGF_CA

EGF_CA: Calcium-binding EGF domain (238 - 263)

Laminin_G_1

Laminin_G_1: Laminin G domain (325 - 452)

Laminin_G_2

Laminin_G_2: Laminin G domain (552 - 650)

  • 0
  • 200
  • 400
  • 600
  • 678 a.a.
蛋白主名 其他名称

growth arrest-specific protein 6

AXL receptor tyrosine kinase ligand

重组 GAS6 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70470 GAS6 Protein, Human (HEK293, Fc) Q14393-2 (A31-A678) ≥95%
HY-P70780 GAS6 Protein, Human (HEK293, His, solution) Q14393-2 (A31-A678) ≥95%
HY-P700724 GAS6 Protein, Human (630a.a, HEK293, His) Q14393-2 (A49-A678) ≥95%

关联疾病

疾病名称 别名
Mesangial Proliferative Glomerulonephritis

Glomerulonephritis - Mesangial Proliferative

Mesangial Proliferative Gn

Mesangioproliferative Glomerulonephritis

Glomerulonephritis Mesangial Proliferative
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Vitamin K Deficiency Bleeding

Vitamin K Deficiency

Deficiency Of Vitamin K

Vitamin K

Vitamin K Deficiency Hemorrhagic Disease
Glomerulonephritis

Bright'S Disease
Ciliary Dyskinesia, Primary, 33

Primary Ciliary Dyskinesia 33

CILD33

Ciliary Dyskinesia, Primary, 33, Without Situs Inversus

Primary Ciliary Dyskinesia 33 Without Situs Inversus
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Parameningeal Embryonal Rhabdomyosarcoma
La Crosse Encephalitis

California Encephalitis

California Virus Encephalitis

Neuroinvasive California Encephalitis Virus Infection

Californian Encephalitis

Encephalitis, California

California Meningoencephalitis

California Encephalitis Virus Infection

California Encephalitis Virus Infection Neuroinvasive Disease

California Meningoencephalitis Virus Disease

California Serogroup Virus Neuroinvasive Disease

California Viral Encephalitis

Ce - [California Encephalitis]

Lac - [La Crosse Encephalitis]
Meckel Syndrome, Type 7

Meckel Syndrome 7

Nphp3-Related Meckel-Like Syndrome

MKS7

Goldston Syndrome

Meckel Syndrome Type 7

Meckel-Like Syndrome Type 1

Renal-Hepatic-Pancreatic Dysplasia-Dandy-Walker Cysts Syndrome

Renal Hepatic Pancreatic Dysplasia Dandy Walker Cyst

Renal-Hepatic-Pancreatic Dysplasia With Dandy-Walker Cyst

Meckel-Gruber Syndrome, Type 7

Dandy-Walker Cyst With Renal-Hepatic-Pancreatic Dysplasia
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Fundus Dystrophy

Retinal Dystrophy

Retinal Dystrophies

Dystrophy, Retinal
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99463 Batiraxcept Inhibitor 96.40% Phase 3
HY-P99161 Tilvestamab Inhibitor 98.08% Phase 1
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119039 RU-301 Inhibitor 99.44% 否
HY-N2995 Poricoic acid A Modulator 98.08% 否
HY-124066 RU-302 Inhibitor 98.02% 否
HY-149092 Anticancer agent 109 / 否
HY-152075 AXL-IN-14 Inhibitor / 否
HY-RS05285 GAS6 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus GAS6 MGD MGI:95660
Bos taurus GAS6 VGNC VGNC:29261
Macaca mulatta GAS6 VGNC VGNC:72885
Canis familiaris GAS6 VGNC VGNC:41118
Felis catus GAS6 VGNC VGNC:62469
Rattus norvegicus GAS6 RGD RGD:61913
Macaca fascicularis GAS6 NCBI NCBI:102133887
Others GAS6 NCBI
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