2. Gene
  3. WDFY4 - WDFY family member 4 Gene

WDFY4 - WDFY family member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：WDFY 家族成员 4

种属: Homo sapiens

同用名: C10orf64

基因 ID: 57705 | 基因类型: protein coding

关于 WDFY4

Cytogenetic location: 10q11.23 Genomic coordinates (GRCh38): 10:48,684,873-48,982,956 (from NCBI)

This gene has 6 transcripts (splice variants), 254 orthologues and 7 paralogues. Biased expression in lymph node (RPKM 13.1), spleen (RPKM 9.3) and 10 other tissues.

功能概要

预测参与细胞自噬。预计在上游或内部对 CD8 阳性 α-β T 细胞活化产生积极影响。预计在抗原加工和呈递以及对病毒的细胞反应的上游或内部起作用。预测位于早期内体和内质网。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to be involved in Autophagy. Predicted to act upstream of or within with a positive effect on CD8-positive, alpha-beta T cell activation. Predicted to act upstream of or within antigen processing and presentation and cellular response to virus. Predicted to be located in early endosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

WDFY4 基因产物(4)

mRNA Protein Name
NM_001370153.1 NP_001357082.1 WD repeat- and FYVE domain-containing protein 4 isoform 2
NM_001370154.1 NP_001357083.1 WD repeat- and FYVE domain-containing protein 4 isoform 3
NM_001394531.1 NP_001381460.1 WD repeat- and FYVE domain-containing protein 4 isoform 1
NM_020945.2 NP_065996.1 WD repeat- and FYVE domain-containing protein 4 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WDFY4 蛋白结构

PH_BEACH

PH_BEACH: PH domain associated with Beige/BEACH (2455 - 2507)

Beach

Beach: Beige/BEACH domain (2540 - 2821)

WD40

WD40: WD domain, G-beta repeat (2976 - 3010)

WD40

WD40: WD domain, G-beta repeat (3065 - 3100)

  • 0
  • 500
  • 1000
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  • 2000
  • 2500
  • 3000
  • 3184 a.a.
蛋白主名 其他名称

WD repeat- and FYVE domain-containing protein 4

关联疾病

疾病名称 别名
Myasthenic Syndrome, Congenital, 6, Presynaptic

Familial Infantile Myasthenia

CMS6

Cmsea

Congenital Myasthenic Syndrome 6

Familial Infantile Myasthenia Gravis 2

Fimg2

Myasthenic Syndrome, Congenital, Associated With Episodic Apnea

Myasthenic Syndrome, Presynaptic, Congenital, Associated With Episodic Apnea

Congenital Myasthenic Syndrome Type Ia2, Formerly

Cms1a2, Formerly

Cms Ia2, Formerly

Myasthenia, Familial Infantile, Formerly

Fim, Formerly

Myasthenia Gravis, Familial Infantile, 2, Formerly

Fimg2, Formerly

Cms Ia2

Cms1a2

Congenital Myasthenic Syndrome 6, Presynaptic

Congenital Myasthenic Syndrome Type Ia2

Congenital Presynaptic Myasthenic Syndrome Associated With Episodic Apnea

Fim

Cms1a

Cms-Ea

Cms Ia

Congenital Myasthenic Syndrome Pre-Synaptic Associated With Episodic Apnea

Congenital Myasthenic Syndrome Type 1a

Congenital Myasthenic Syndrome Type Ia

Myasthenic Syndrome, Congenital, Type 6, Presynaptic
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15757 WDFY4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus WDFY4 MGD MGI:3584510
Rattus norvegicus WDFY4 RGD RGD:1564142
Canis familiaris WDFY4 VGNC VGNC:53018
Macaca mulatta WDFY4 VGNC VGNC:106120
Felis catus WDFY4 VGNC VGNC:109517
Bos taurus WDFY4 VGNC VGNC:55999
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