2. Gene
  3. MIER1 - MIER1 transcriptional regulator Gene

MIER1 - MIER1 transcriptional regulator Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MIER1 转录调控因子

种属: Homo sapiens

同用名: ER1; MI-ER1

基因 ID: 57708 | 基因类型: protein coding

关于 MIER1

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:66,924,990-66,988,619 (from NCBI)

This gene has 11 transcripts (splice variants), 223 orthologues and 5 paralogues. Ubiquitous expression in bone marrow (RPKM 19.6), colon (RPKM 10.3) and 24 other tissues.

功能概要

该基因编码的蛋白质首先在非洲爪蟾中通过其在中胚层诱导早期反应 (MIER) 中的作用而被发现。编码的蛋白质起到转录调节剂的作用。选择性剪接的转录物变体编码多种亚型，其中一些缺乏 C 端核定位信号。[RefSeq 提供，2013 年 5 月]

This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). The encoded protein functions as a transcriptional regulator. Alternatively spliced transcript variants encode multiple isoforms, some of which lack a C-terminal nuclear localization signal. [provided by RefSeq, May 2013]

MIER1 基因产物(12)

mRNA Protein Name
NM_001077700.3 NP_001071168.2 mesoderm induction early response protein 1 isoform b
NM_001077701.3 NP_001071169.1 mesoderm induction early response protein 1 isoform c
NM_001077702.3 NP_001071170.2 mesoderm induction early response protein 1 isoform d precursor
NM_001077703.3 NP_001071171.2 mesoderm induction early response protein 1 isoform e
NM_001077704.3 NP_001071172.1 mesoderm induction early response protein 1 isoform f
NM_001146110.2 NP_001139582.1 mesoderm induction early response protein 1 isoform a precursor
NM_001146111.2 NP_001139583.1 mesoderm induction early response protein 1 isoform g precursor
NM_001146112.2 NP_001139584.1 mesoderm induction early response protein 1 isoform h
NM_001146113.2 NP_001139585.1 mesoderm induction early response protein 1 isoform i
NM_001278215.2 NP_001265144.1 mesoderm induction early response protein 1 isoform j precursor
NM_001350530.2 NP_001337459.1 mesoderm induction early response protein 1 isoform k
NM_020948.4 NP_065999.2 mesoderm induction early response protein 1 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to histone deacetylase activity IDA
IDA: 通过直接分析推断
28046085 GOA
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
28046085 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12482978 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IDA
IDA: 通过直接分析推断
12482978 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12482978 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
28046085 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
28046085 GOA
part of transcription repressor complex IDA
IDA: 通过直接分析推断
12482978 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MIER1 蛋白结构

ELM2

ELM2: ELM2 domain (182 - 234)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 512 a.a.
蛋白主名 其他名称

mesoderm induction early response protein 1

mesoderm induction early response 1 homolog

关联疾病

疾病名称 别名
Inflammatory Bowel Disease 2

IBD2
Frozen Shoulder

Adhesive Capsulitis Of Shoulder

Bursitis

Adhesions-Capsulitis,Shoulder

Pericapsulitis Of Shoulder

Duplay Bursitis

Adhesive Shoulder Peritendinitis

Subscapular Adhesion

Shoulder Adhesion

Adhesive Enthesopathy Of Shoulder Region

Adhesive Peritendinitis

Adhesive Shoulder Tenosynovitis

Duplay Periarthritis

Adhesive Shoulder Tendinitis
Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome

Ers

Amelogenesis Imperfecta Type 1g

AI1G

Enamel-Renal-Gingival Syndrome

Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

Aigfs

Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

Amelogenesis Imperfecta Type Ig

Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

Amelogenesis Imperfecta 1g

Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

Amelogenesis Imperfecta Nephrocalcinosis
Calcific Tendinitis

Calcific Tendinitis Nos
Teeth Hard Tissue Disease
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08442 MIER1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus MIER1 VGNC VGNC:31469
Canis familiaris MIER1 VGNC VGNC:43229
Felis catus MIER1 VGNC VGNC:63500
Macaca mulatta MIER1 VGNC VGNC:74862
Rattus norvegicus MIER1 RGD RGD:1562337
Mus musculus MIER1 MGD MGI:1918398
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