2. Gene
  3. SCUBE2 - signal peptide, CUB domain and EGF like domain containing 2 Gene

SCUBE2 - signal peptide, CUB domain and EGF like domain containing 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含信号肽、CUB 结构域和 EGF 样结构域 2

种属: Homo sapiens

同用名: CEGB1; CEGF1; CEGP1; scube/You

基因 ID: 57758 | 基因类型: protein coding

关于 SCUBE2

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:9,019,476-9,091,599 (from NCBI)

This gene has 14 transcripts (splice variants), 209 orthologues and 2 paralogues. Broad expression in prostate (RPKM 8.1), urinary bladder (RPKM 7.3) and 20 other tissues.

功能概要

预测可启用钙离子结合活性；刺猬家族蛋白结合活性；和脂质结合活性。预计参与信号转导。预计在几个过程的上游或内部起作用，包括软骨细胞增殖的正调节；成骨细胞分化的正调节；和平滑信号通路的正调节。预测位于细胞外区域。预计在细胞表面和细胞外空间有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable calcium ion binding activity; Hedgehog family protein binding activity; and lipid binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including positive regulation of chondrocyte proliferation; positive regulation of osteoblast differentiation; and positive regulation of smoothened signaling pathway. Predicted to be located in extracellular region. Predicted to be active in cell surface and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SCUBE2 基因产物(4)

mRNA Protein Name
NM_001170690.3 NP_001164161.1 signal peptide, CUB and EGF-like domain-containing protein 2 isoform 2 precursor
NM_001330199.3 NP_001317128.1 signal peptide, CUB and EGF-like domain-containing protein 2 isoform 3 precursor
NM_001367977.2 NP_001354906.1 signal peptide, CUB and EGF-like domain-containing protein 2 isoform 4 precursor
NM_020974.4 NP_066025.2 signal peptide, CUB and EGF-like domain-containing protein 2 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12270931 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SCUBE2 蛋白结构

EGF_CA

EGF_CA: Calcium-binding EGF domain (45 - 84)

cEGF

cEGF: Complement Clr-like EGF-like (109 - 131)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (132 - 167)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (286 - 321)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (327 - 362)

EGF_CA

EGF_CA: Calcium-binding EGF domain (364 - 394)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (407 - 442)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (673 - 720)

Ephrin_rec_like

Ephrin_rec_like: Putative ephrin-receptor like (729 - 776)

CUB

CUB: CUB domain (781 - 890)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 971 a.a.
蛋白主名 其他名称

signal peptide, CUB and EGF-like domain-containing protein 2

关联疾病

疾病名称 别名
Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation

Intracranial Arteriovenous Malformation

Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

Intracranial Arteriovenous Malformations

Bavm

Cerebral Arteriovenous Malformations

Intracranial Hemorrhage In Brain Cerebrovascular Malformations

Arteriovenous Malformation Of The Brain, Somatic

Intracranial Avm

Arteriovenous Malformations Cerebral
Central Nervous System Tuberculosis

Intracranial Tuberculoma

Tuberculoma Of Brain

Tuberculosis Of Meninges And Central Nervous System

Tuberculous Abscess Of Brain

Tuberculoma, Intracranial

Tuberculosis, Central Nervous System
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12572 SCUBE2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SCUBE2 RGD RGD:1563998
Felis catus SCUBE2 VGNC VGNC:64938
Canis familiaris SCUBE2 VGNC VGNC:45936
Bos taurus SCUBE2 VGNC VGNC:34372
Macaca mulatta SCUBE2 VGNC VGNC:77138
Mus musculus SCUBE2 MGD MGI:1928765
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