2. Gene
  3. CADM3 - cell adhesion molecule 3 Gene

CADM3 - cell adhesion molecule 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞粘附分子 3

种属: Homo sapiens

同用名: BIgR; NECL1; TSLL1; CMT2FF; IGSF4B; Necl-1; synCAM3

基因 ID: 57863 | 基因类型: protein coding

关于 CADM3

Cytogenetic location: 1q23.2 Genomic coordinates (GRCh38): 1:159,171,615-159,203,313 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 1 phenotype. Biased expression in brain (RPKM 106.6), placenta (RPKM 39.2) and 4 other tissues.

功能概要

该基因编码的蛋白质是一种钙非依赖性细胞间粘附蛋白，可与其他 nectin 蛋白形成同源二聚体或异源二聚体。编码的蛋白质具有嗜同性和异嗜性细胞-细胞粘附活性。据报道，该基因是一种肿瘤抑制基因。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene is a calcium-independent cell-cell adhesion protein that can form homodimers or heterodimers with other nectin proteins. The encoded protein has both homophilic and heterophilic cell-cell adhesion activity. This gene is reported to be a tumor suppressor gene. [provided by RefSeq, Oct 2016]

CADM3 基因产物(3)

mRNA Protein Name
NM_001127173.3 NP_001120645.1 cell adhesion molecule 3 isoform 2 precursor
NM_001346510.2 NP_001333439.1 cell adhesion molecule 3 isoform 3 precursor
NM_021189.5 NP_067012.1 cell adhesion molecule 3 isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CADM3 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (37 - 117)

C2-set_2

C2-set_2: CD80-like C2-set immunoglobulin domain (135 - 218)

Ig_2

Ig_2: Immunoglobulin domain (237 - 315)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
蛋白主名 其他名称

cell adhesion molecule 3

TSLC1-like 1

重组 CADM3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70083 CADM3 Protein, Human (HEK293, His) Q8N126-1 (N25-H330) ≥95%

关联疾病

疾病名称 别名
Charcot-Marie-Tooth Disease, Axonal, Type 2ff

CMT2FF

Charcot-Marie-Tooth Neuropathy, Type 2ff

Charcot-Marie-Tooth Disease 2ff
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome

Orofacial Cleft 7

Zlotogora-Ogur Syndrome

CLPED1

Ectodermal Dysplasia, Margarita Island Type

Ed4

Cleft Lip-Palate-Ectodermal Dysplasia Syndrome

Cleft Lip/Palate-Syndactyly-Pili Torti Syndrome

Syndactyly-Ectodermal Dysplasia-Cleft/Lip Palate

Ectodermal Dysplasia 4

Ectodermal Dysplasia Margarita Type

Ectodermal Dysplasia, Type 4

Ectodermal Dysplasia, Cleft Lip And Palate, Mental Retardation, And Syndactyly

Margarita Type Of Ectodermal Dysplasia

Zlotogora-Zilberman-Tenenbaum Syndrome

Ectd4

Ectodermal Dysplasia 4, Hair/Nail Type

EDMI

Ectodermal Dysplasia Type 4

Margarita Island Ectodermal Dysplasia

Syndactyly-Ectodermal Dysplasia-Cleft Lip/Palate

Non-Syndromic Orofacial Cleft 7

OFC7

Non-Syndromic Cleft Lip/Palate 7

Non-Syndromic Cleft Lip With Or Without Cleft Palate 7
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Tooth Disease

Tooth Diseases

Teeth Disease

Tooth Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01821 CADM3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CADM3 RGD RGD:1307035
Mus musculus CADM3 MGD MGI:2137858
Canis familiaris CADM3 VGNC VGNC:38657
Bos taurus CADM3 VGNC VGNC:26696
Macaca mulatta CADM3 VGNC VGNC:70574
Felis catus CADM3 VGNC VGNC:60314
Macaca fascicularis CADM3 NCBI NCBI:102129491
Others CADM3 NCBI
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