2. Gene
  3. PTPRO - protein tyrosine phosphatase receptor type O Gene

PTPRO - protein tyrosine phosphatase receptor type O Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：O 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: NPHS6; PTPU2; GLEPP1; PTP-OC; PTP-U2; PTPROT; R-PTP-O

基因 ID: 5800 | 基因类型: protein coding

关于 PTPRO

Cytogenetic location: 12p12.3 Genomic coordinates (GRCh38): 12:15,322,508-15,598,331 (from NCBI)

This gene has 26 transcripts (splice variants), 220 orthologues, 35 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 3.7), brain (RPKM 2.7) and 11 other tissues.

功能概要

该基因编码受体型蛋白酪氨酸磷酸酶 R3 亚型家族的成员。这些蛋白质定位于极化细胞的顶端表面，并可能通过激活 Src 家族激酶而具有组织特异性功能。该基因包含两个不同的启动子，并且已经观察到编码多种同种型的选择性剪接转录物变体。编码的蛋白质可能具有多种异构体特异性和组织特异性功能，包括调节破骨细胞的产生和活性、抑制细胞增殖和促进细胞凋亡。该基因是候选肿瘤抑制因子，并且已在多种类型的癌症中观察到该基因的表达降低。[RefSeq 提供，2011 年 5 月]

This gene encodes a member of the R3 subtype family of receptor-type Protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of Apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of Cancer. [provided by RefSeq, May 2011]

PTPRO 基因产物(6)

mRNA Protein Name
NM_002848.4 NP_002839.1 receptor-type tyrosine-protein phosphatase O isoform b precursor
NM_030667.3 NP_109592.1 receptor-type tyrosine-protein phosphatase O isoform a precursor
NM_030668.3 NP_109593.1 receptor-type tyrosine-protein phosphatase O isoform d
NM_030669.3 NP_109594.1 receptor-type tyrosine-protein phosphatase O isoform c
NM_030670.3 NP_109595.1 receptor-type tyrosine-protein phosphatase O isoform d
NM_030671.3 NP_109596.1 receptor-type tyrosine-protein phosphatase O isoform c
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadherin binding IPI
IPI: 通过物理相互作用推断
28926625 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19167335 GOA
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
19167335 GOA
enables protein tyrosine phosphatase activity IMP
IMP: 通过突变表型推断
19233845 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glomerulus development IMP
IMP: 通过突变表型推断
21722858 GOA
involved in monocyte chemotaxis IMP
IMP: 通过突变表型推断
19233845 GOA
involved in peptidyl-tyrosine dephosphorylation IMP
IMP: 通过突变表型推断
19233845 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PTPRO 蛋白结构

fn3

fn3: Fibronectin type III domain (435 - 521)

fn3

fn3: Fibronectin type III domain (725 - 800)

Y_phosphatase

Y_phosphatase: Protein-tyrosine phosphatase (962 - 1193)

  • 0
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  • 1000
  • 1216 a.a.
蛋白主名 其他名称

receptor-type tyrosine-protein phosphatase O

PTP phi

PTPRO 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PTPRO Q16827 MET Homo sapiens P08581
Phosphatase Assay
19167335
种属内
PTPRO Q16827 MET Homo sapiens P08581
Pull Down
28330616
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephrotic Syndrome, Type 6

NPHS6

Nephrotic Syndrome Type 6

Nephrotic Syndrome 6
Genetic Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Genetic Srns

Hereditary Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Nephrotic Syndrome

Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive

Srn1
Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome

Focal Glomerulosclerosis

Fsgs

Segmental Glomerulosclerosis

Glomerulosclerosis, Focal Segmental

Fgs

Focal Glomerular Sclerosis

Familial Idiopathic Nephrotic Syndrome

Focal Sclerosis With Hyalinosis

Glomerulosclerosis, Focal

Glomerulosclerosis Focal

Glomerulosclerosis, Segmental, Focal

Focal Segmental Glomerulosclerosis, Not Otherwise Specified
Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome

Ns - [Nephrotic Syndrome]

Nephrosis Syndrome

Nephrosis Nos

Glomerular Lesion Nephrosis
Focal Segmental Glomerulosclerosis 7

FSGS7

Glomerulosclerosis, Focal Segmental, 7

Glomerulosclerosis, Focal Segmental, Type 7
Focal Segmental Glomerulosclerosis 9

FSGS9

Glomerulosclerosis, Focal Segmental, 9

Glomerulosclerosis, Focal Segmental, Type 9
Familial Nephrotic Syndrome

Congenital Nephrotic Syndrome

Nephrosis, Congenital

Finnish Congenital Nephrotic Syndrome
Galloway-Mowat Syndrome

Galloway Mowat Syndrome

Galloway Syndrome

Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type

Microcephaly Nephrosis Syndrome

Microcephaly, Hiatal Hernia, And Nephrotic Syndrome

Nephrosis Neuronal Dysmigration Syndrome

Microcephaly-Hiatus Hernia-Nephrotic Syndrome

Nephrosis-Neuronal Dysmigration Syndrome
Alport Syndrome

Hereditary Nephritis

Alport Syndrome, X-Linked

Hemorrhagic Hereditary Nephritis

Congenital Hereditary Hematuria

Hemorrhagic Familial Nephritis

Familial Nephritis

Thin Basement Membrane Disease

Thin Basement Membrane Nephropathy

Hematuria-Nephropathy-Deafness Syndrome

Hematuric Hereditary Nephritis

Hereditary Familial Congenital Hemorrhagic Nephritis

Hereditary Hematuria Syndrome

Hereditary Interstitial Pyelonephritis

Alport Deafness-Nephropathy

Alport Hearing Loss-Nephropathy

Alports Syndrome

Nephritis, Hereditary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11446 PTPRO Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PTPRO VGNC VGNC:45195
Macaca mulatta PTPRO VGNC VGNC:100096
Bos taurus PTPRO VGNC VGNC:33555
Felis catus PTPRO VGNC VGNC:69179
Rattus norvegicus PTPRO RGD RGD:62068
Mus musculus PTPRO MGD MGI:1097152
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