2. Gene
  3. TP53INP2 - tumor protein p53 inducible nuclear protein 2 Gene

TP53INP2 - tumor protein p53 inducible nuclear protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肿瘤蛋白 p53 诱导核蛋白 2

种属: Homo sapiens

同用名: DOR; PIGU; PINH; PIG-U; C20orf110; dJ1181N3.1

基因 ID: 58476 | 基因类型: protein coding

关于 TP53INP2

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,704,344-34,713,436 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 35.1), brain (RPKM 34.7) and 25 other tissues.

功能概要

由该基因编码的蛋白质促进自噬，并且对于适当的自噬体形成和加工至关重要。此外，编码的蛋白质可以通过帮助组装 POLR1/RNA 聚合酶 I 预起始复合物来增强 rDNA 转录。最后，这种蛋白质可作为某些基因的转录激活剂。[RefSeq 提供，2016 年 7 月]

The protein encoded by this gene promotes Autophagy and is essential for proper autophagosome formation and processing. In addition, the encoded protein can enhance rDNA transcription by helping in the assembly of the POLR1/RNA polymerase I preinitiation complex. Finally, this protein serves as a transcriptional activator for some genes. [provided by RefSeq, Jul 2016]

TP53INP2 基因产物(4)

mRNA Protein Name
NM_001329429.2 NP_001316358.1 tumor protein p53-inducible nuclear protein 2
NM_001329430.2 NP_001316359.1 tumor protein p53-inducible nuclear protein 2
NM_001329431.2 NP_001316360.1 tumor protein p53-inducible nuclear protein 2
NM_021202.3 NP_067025.1 tumor protein p53-inducible nuclear protein 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19056683 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagosome assembly IDA
IDA: 通过直接分析推断
19056683 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
22470510 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in autophagosome IDA
IDA: 通过直接分析推断
19056683 GOA
located in cytosol IDA
IDA: 通过直接分析推断
22470510 GOA
located in nucleus IDA
IDA: 通过直接分析推断
19056683 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TP53INP2 蛋白结构

DOR

DOR: DOR family (28 - 217)

  • 0
  • 100
  • 200
  • 220 a.a.
蛋白主名 其他名称

tumor protein p53-inducible nuclear protein 2

diabetes and obesity-regulated

关联疾病

疾病名称 别名
Branchiootorenal Syndrome 2

BOR2

Bor Syndrome 2

Branchiootorenal Dysplasia 2

Branchio-Oto-Renal Dysplasia 2

Branchio-Oto-Renal Syndrome Type 2

Branchiootorenal Syndrome, Type 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14921 TP53INP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TP53INP2 MGD MGI:1915978
Bos taurus TP53INP2 VGNC VGNC:36237
Macaca mulatta TP53INP2 VGNC VGNC:108068
Rattus norvegicus TP53INP2 RGD RGD:735085
Canis familiaris TP53INP2 VGNC VGNC:47726
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