1. Gene
  2. LY6G6D - lymphocyte antigen 6 family member G6D Gene

LY6G6D - lymphocyte antigen 6 family member G6D Gene

中文名称:淋巴细胞抗原 6 家族成员 G6D

种属: Homo sapiens

同用名: G6D; NG25; LY6-D; MEGT1; C6orf23

基因 ID: 58530 | 基因类型: protein coding

关于 LY6G6D

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,715,348-31,717,919 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 56 orthologues and 1 paralogue. Biased expression in prostate (RPKM 1.8), testis (RPKM 1.5) and 6 other tissues.

功能概要

LY6G6D 属于白细胞抗原 6 (LY6) 基因簇,位于 6 号染色体上的主要组织相容性复合体 (MHC) III 类区域。LY6 超家族的成员通常包含 70 至 80 个氨基酸,包括 8 至 10 个半胱氨酸。大多数 LY6 蛋白通过直接参与信号转导的糖基磷脂酰肌醇 (GPI) 锚附着在细胞表面 (Mallya 等人,2002 [PubMed 12079290]) 。[OMIM 提供,2009 年 4 月]

LY6G6D belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 Amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Apr 2009]

LY6G6D 基因产物(1)

mRNA Protein Name
NM_021246.4 NP_067069.2 lymphocyte antigen 6 complex locus protein G6d precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
17008713 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
colocalizes with external side of plasma membrane IDA
IDA: 通过直接分析推断
17008713 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
17008713 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

lymphocyte antigen 6 complex locus protein G6d

lymphocyte antigen 6 complex, locus G6D

LY6G6D 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LY6G6D O95868 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
LY6G6D O95868 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
LY6G6D O95868 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
LY6G6D O95868 HSPA5 Homo sapiens P11021
Anti Tag CoIP
33961781
种属内
LY6G6D O95868 NCS1 Homo sapiens P62166
Validated Y2H
32296183
种属内
LY6G6D O95868 NCALD Homo sapiens P61601
Validated Y2H
32296183
种属内
LY6G6D O95868 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LY6G6D 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71751 LY6G6D Protein, Human (P.pastoris, His) O95868 (N20-S104) ≥95%

关联疾病

疾病名称 别名
Glucosephosphate Dehydrogenase Deficiency

G6pd Deficiency

Glucose-6-Phosphate Dehydrogenase Deficiency

Deficiency Of Glucose-6-Phosphate Dehydrogenase

Glucose 6 Phosphate Dehydrogenase Deficiency

Deficiency Of G-6pd

G6pdd

Anemia, Nonspherocytic Hemolytic, Due To G6pd Deficiency

Favism

Favism, Susceptibility To

Hemolytic Anemia, G6pd Deficient

Class I Glucose-6-Phosphate Dehydrogenase Deficiency

Class I G6pd Deficiency

Severe Hemolytic Anemia Due To G6pd Deficiency

Anemia, Non-Spherocytic Hemolytic, Due To G6pd Deficiency

NSHA

G6pd Deficient Hemolytic Anemia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris LY6G6D VGNC VGNC:106603
Rattus norvegicus LY6G6D RGD RGD:1303064
Bos taurus LY6G6D VGNC VGNC:54228
Mus musculus LY6G6D MGD MGI:2148931
Macaca fascicularis LY6G6D NCBI
Others LY6G6D NCBI