2. Gene
  3. RAD51B - RAD51 paralog B Gene

RAD51B - RAD51 paralog B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAD51 旁系同源 B

种属: Homo sapiens

同用名: REC2; R51H2; RAD51L1

基因 ID: 5890 | 基因类型: protein coding

关于 RAD51B

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:67,819,779-68,683,096 (from NCBI)

This gene has 24 transcripts (splice variants), 151 orthologues, 6 paralogues and is associated with 77 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质是 RAD51 蛋白质家族的成员。 RAD51 家族成员是通过同源重组进行 DNA 修复所必需的进化保守蛋白。该蛋白已被证明与家族成员 RAD51C 形成稳定的异二聚体，后者进一步与其他家族成员相互作用，例如 RAD51、XRCC2 和 XRCC3。发现该基因的过度表达会导致细胞周期 G1 延迟和细胞凋亡，这表明该蛋白质在感知 DNA 损伤中的作用。已在子宫平滑肌瘤中观察到该基因座与高迁移率组 AT-hook 2 (HMGA2，GeneID 8091) 之间的重排。[RefSeq 提供，2016 年 3 月]

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are evolutionarily conserved proteins essential for DNA repair by homologous recombination. This protein has been shown to form a stable heterodimer with the family member RAD51C, which further interacts with the other family members, such as RAD51, XRCC2, and XRCC3. Overexpression of this gene was found to cause cell cycle G1 delay and cell Apoptosis, which suggested a role of this protein in sensing DNA damage. Rearrangements between this locus and high mobility group AT-hook 2 (HMGA2, GeneID 8091) have been observed in uterine leiomyomata. [provided by RefSeq, Mar 2016]

RAD51B 基因产物(12)

mRNA Protein Name
NM_001321809.2 NP_001308738.1 DNA repair protein RAD51 homolog 2 isoform 4
NM_001321810.2 NP_001308739.1 DNA repair protein RAD51 homolog 2 isoform 4
NM_001321812.1 NP_001308741.1 DNA repair protein RAD51 homolog 2 isoform 5
NM_001321814.2 NP_001308743.1 DNA repair protein RAD51 homolog 2 isoform 5
NM_001321815.1 NP_001308744.1 DNA repair protein RAD51 homolog 2 isoform 6
NM_001321817.2 NP_001308746.1 DNA repair protein RAD51 homolog 2 isoform 10
NM_001321818.2 NP_001308747.1 DNA repair protein RAD51 homolog 2 isoform 7
NM_001321819.1 NP_001308748.1 DNA repair protein RAD51 homolog 2 isoform 8
NM_001321821.2 NP_001308750.1 DNA repair protein RAD51 homolog 2 isoform 9
NM_002877.6 NP_002868.1 DNA repair protein RAD51 homolog 2 isoform 1
NM_133509.5 NP_598193.2 DNA repair protein RAD51 homolog 2 isoform 3
NM_133510.4 NP_598194.1 DNA repair protein RAD51 homolog 2 isoform 2

RAD51B 蛋白结构

Rad51

Rad51: Rad51 (82 - 342)

  • 0
  • 100
  • 200
  • 300
  • 384 a.a.
蛋白主名 其他名称

DNA repair protein RAD51 homolog 2

RAD51 homolog B

RAD51B 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RAD51B O15315 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Intra RAD51B O15315 RAD51D Homo sapiens O75771
Anti Tag CoIP
33961781
Intra RAD51B O15315 RAD51D Homo sapiens O75771
Electrophoresis
11751635
Intra RAD51B O15315 RAD51D Homo sapiens O75771
GMS
11751635
Intra RAD51B O15315 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra RAD51B O15315 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra RAD51B O15315 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra RAD51B O15315 RAD51C Homo sapiens O43502
Anti Tag CoIP
33961781
Intra RAD51B O15315 RAD51C Homo sapiens O43502
GMS
11751635
Intra RAD51B O15315 RAD51C Homo sapiens O43502
Y2H
9469824
Intra RAD51B O15315 RAD51C Homo sapiens O43502
Anti Bait CoIP
11842113
Intra RAD51B O15315 RAD51C Homo sapiens O43502
Electrophoresis
11751635
Intra RAD51B O15315 RPAIN Homo sapiens Q86UA6
Y2H Array
32296183
Intra RAD51B O15315 RPAIN Homo sapiens Q86UA6
Y2H Prey Pooling
32296183
Intra RAD51B O15315 RPAIN Homo sapiens Q86UA6
Validated Y2H
32296183
Intra RAD51B O15315 SWSAP1 Homo sapiens Q6NVH7
Anti Tag CoIP
21965664
Intra RAD51B O15315 SWSAP1 Homo sapiens Q6NVH7
Pull Down
21965664
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leiomyoma

Leiomyomatous Neoplasm

Leiomyomatous Tumor

Leiomyomas

Fibroid Tumor

Uterine Fibroids
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Alcoholic Psychosis

Psychoses, Alcoholic

Alcoholic Psychoses
Leiomyoma, Uterine

Uterine Leiomyoma

Uterine Fibroid

Uterine Fibroids

Plexiform Leiomyoma

UL

Leiomyoma Of Corpus Uteri

Uterus Fibroma
Alcohol-Induced Mental Disorder

Psychoses, Alcoholic
Rectum Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Rectum

Rectal Squamous Cell Carcinoma

Squamous Carcinoma Of Rectum
Macular Degeneration, Age-Related, 1

Macular Degeneration

Age-Related Macular Degeneration

Macular Degeneration, Age-Related

Age Related Macular Degeneration

Age Related Macular Degeneration 1

ARMD1

Senile Macular Degeneration

Maculopathy, Age-Related, 1

Macular Degeneration, Age-Related, Reduced Risk Of

Age Related Maculopathy 1

Age Related Maculopathies

Age Related Maculopathy

Senile Macular Retinal Degeneration

Macular Degeneration Of Retina

Age-Related Maculopathy

Amd

Armd

Age-Related Maculopathy, Susceptibility To

Maculopathy Age-Related

Macular Degeneration, Age-Related, 1, Susceptibility To

Maculopathy, Age-Related

Macular Degeneration, Age-Related, Type 1

Macular Degeneration, Age-Related, 2
Cervix Melanoma
Plantar Fascial Fibromatosis

Dupuytren'S Contracture Of Foot

Ledderhose'S Disease

Fibromatosis, Plantar

Ledderhose Disease
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Uterine Benign Neoplasm
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11607 RAD51B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RAD51B VGNC VGNC:76647
Felis catus RAD51B VGNC VGNC:80873
Mus musculus RAD51B MGD MGI:1099436
Bos taurus RAD51B VGNC VGNC:33685
Rattus norvegicus RAD51B RGD RGD:1560681
Canis familiaris RAD51B VGNC VGNC:82294
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