RAP1GAP - RAP1 GTPase activating protein Gene

中文名称：RAP1 GTP 酶激活蛋白

种属: Homo sapiens

同用名: RAPGAP; RAP1GA1; RAP1GAP1; RAP1GAPII

关于 RAP1GAP

功能概要

该基因编码一种 GTP 酶激活蛋白 (GAP) ，可下调与 Ras 相关的 RAP1 蛋白的活性。 RAP1 通过在非活性 GDP 结合形式和活性 GTP 结合形式之间循环来充当分子开关。该基因的产物 RAP1GAP 促进结合 GTP 的水解，从而使 RAP1 恢复到非活性状态，而其他蛋白质，鸟嘌呤核苷酸交换因子 (GEF) ，通过促进 RAP1 从 GDP- 到 GTP 结合形式。一般来说，Ras 亚家族蛋白，如 RAP1，在控制细胞生长和分化的受体相关信号通路中起着关键作用。 RAP1 在细胞增殖、粘附、分化和胚胎发生等多种过程中发挥作用。可变剪接导致编码不同蛋白质的多个转录变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a type of GTPase-activating-protein (GAP) that down-regulates the activity of the ras-related RAP1 protein. RAP1 acts as a molecular switch by cycling between an inactive GDP-bound form and an active GTP-bound form. The product of this gene, RAP1GAP, promotes the hydrolysis of bound GTP and hence returns RAP1 to the inactive state whereas Other proteins, guanine nucleotide exchange factors (GEFs), act as RAP1 activators by facilitating the conversion of RAP1 from the GDP- to the GTP-bound form. In general, Ras subfamily proteins, such as RAP1, play key roles in receptor-linked signaling pathways that control cell growth and differentiation. RAP1 plays a role in diverse processes such as cell proliferation, adhesion, differentiation, and embryogenesis. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Aug 2011]