2. Gene
  3. RBM4 - RNA binding motif protein 4 Gene

RBM4 - RNA binding motif protein 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RNA 结合基序蛋白 4

种属: Homo sapiens

同用名: LARK; RBM4A; ZCRB3A; ZCCHC21

基因 ID: 5936 | 基因类型: protein coding

关于 RBM4

Cytogenetic location: 11q13.2 Genomic coordinates (GRCh38): 11:66,638,703-66,668,380 (from NCBI)

This gene has 13 transcripts (splice variants), 72 orthologues and 36 paralogues. Ubiquitous expression in lymph node (RPKM 17.5), ovary (RPKM 17.2) and 25 other tissues.

功能概要

启用 RNA 结合活性和细胞周期蛋白结合活性。参与多个过程，包括线性 mRNA 的 IRES 依赖性翻译起始；翻译的负调节；和通过剪接体调节可变 mRNA 剪接。位于细胞质应激颗粒；胞质溶胶；和核腔。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA binding activity and cyclin binding activity. Involved in several processes, including IRES-dependent translational initiation of linear mRNA; negative regulation of translation; and regulation of alternative mRNA splicing, via spliceosome. Located in cytoplasmic stress granule; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]

RBM4 基因产物(3)

mRNA Protein Name
NM_001198843.2 NP_001185772.1 RNA-binding protein 4 isoform 2
NM_001198844.2 NP_001185773.1 RNA-binding protein 4 isoform 3
NM_002896.4 NP_002887.2 RNA-binding protein 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
19561594 GOA
enables cyclin binding IPI
IPI: 通过物理相互作用推断
15159402 GOA
enables mRNA binding IDA
IDA: 通过直接分析推断
21518792 GOA
enables miRNA binding IDA
IDA: 通过直接分析推断
19801630 GOA
enables pre-mRNA intronic binding IDA
IDA: 通过直接分析推断
16260624 GOA
enables pre-mRNA intronic pyrimidine-rich binding IDA
IDA: 通过直接分析推断
16260624 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12628928 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in IRES-dependent translational initiation of linear mRNA IDA
IDA: 通过直接分析推断
17284590 GOA
involved in cap-independent translational initiation IDA
IDA: 通过直接分析推断
17284590 GOA
involved in miRNA-mediated gene silencing by inhibition of translation IDA
IDA: 通过直接分析推断
19801630 GOA
involved in negative regulation of translation IDA
IDA: 通过直接分析推断
17284590 GOA
involved in negative regulation of translation in response to stress IDA
IDA: 通过直接分析推断
17284590 GOA
involved in negative regulation of translational initiation IDA
IDA: 通过直接分析推断
19801630 GOA
involved in positive regulation of muscle cell differentiation IDA
IDA: 通过直接分析推断
21518792 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
12628928 GOA
involved in regulation of nucleocytoplasmic transport IDA
IDA: 通过直接分析推断
12628928 GOA
involved in response to arsenic-containing substance IDA
IDA: 通过直接分析推断
17284590 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12628928 GOA
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
17284590 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
12628928 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
12628928 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
12628928 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16777844 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RBM4 蛋白结构

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (4 - 64)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (81 - 141)

zf-CCHC

zf-CCHC: Zinc knuckle (161 - 176)

  • 0
  • 100
  • 200
  • 300
  • 364 a.a.
蛋白主名 其他名称

RNA-binding protein 4

RNA-binding motif protein 4a

RBM4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RBM4 Q9BWF3 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
种属内
RBM4 Q9BWF3 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
种属内
RBM4 Q9BWF3 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
种属内
RBM4 Q9BWF3 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
RBM4 Q9BWF3 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
RBM4 Q9BWF3 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11752 RBM4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus RBM4 MGD MGI:1100865
Rattus norvegicus RBM4 RGD RGD:1306891
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