RGS10 - regulator of G protein signaling 10 Gene

中文名称：G 蛋白信号调节器 10

种属: Homo sapiens

关于 RGS10

功能概要

蛋白信号转导调节子 (RGS) 家族成员是调节分子，可作为异源三聚体 G 蛋白的 G α 亚基的 GTP 酶激活蛋白 (GAP) 。 RGS 蛋白能够使 Gi α、Go α 和 Gq α 亚型的 G 蛋白亚基失活。它们将 G 蛋白驱动为无活性的 GDP 结合形式。 G 蛋白信号调节器 10 属于该家族。所有 RGS 蛋白都共享一个保守的 120 个氨基酸序列，称为 RGS 结构域。这种蛋白质与两个相关 G 蛋白亚基 G-alphai3 和 G-alphaz 的活化形式特异性结合，但不能与结构和功能不同的 G-alpha 亚基相互作用。 G 蛋白信号调节器 10 蛋白位于细胞核中。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2008 年 7 月]

Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]