1. Gene
  2. RLF - RLF zinc finger Gene

RLF - RLF zinc finger Gene

中文名称:RLF 锌指

种属: Homo sapiens

同用名: ZN-15L; ZNF292L

基因 ID: 6018 | 基因类型: protein coding

关于 RLF

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,161,387-40,240,921 (from NCBI)

This gene has 1 transcript (splice variant), 214 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 13.7), testis (RPKM 7.9) and 25 other tissues.

功能概要

预测启用 DNA 结合活性和 DNA 结合转录激活剂活性,RNA 聚合酶 II 特异性。预测参与 RNA 聚合酶 II 对转录的正调控。预计在组蛋白 H3-K4 单甲基化和 DNA 甲基化调节的上游或内部起作用。预计活跃于核心。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable DNA binding activity and DNA-binding transcription activator activity, RNA polymerase II-specific. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within histone H3-K4 monomethylation and regulation of DNA methylation. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

RLF 基因产物(1)

mRNA Protein Name
NM_012421.4 NP_036553.2 zinc finger protein Rlf
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
10545207 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RLF 蛋白结构

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (671 - 696)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (954 - 979)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1172 - 1195)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (1310 - 1335)

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  • 1914 a.a.
蛋白主名 其他名称

zinc finger protein Rlf

Zn-15 related

RLF 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
RLF Q13129 Q99IB8-PRO_0000045603 Hepatitis C virus Q99IB8-PRO_0000045603
Y2H
24136289
种属间
RLF Q13129 Q99IB8-PRO_0000045603 Hepatitis C virus Q99IB8-PRO_0000045603 24136289
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Left Ventricular Noncompaction

Noncompaction Cardiomyopathy

Left Ventricular Hypertrabeculation

Lvnc

Spongy Myocardium

Isolated Noncompaction Of The Ventricular Myocardium

Left Ventricular Myocardial Noncompaction Cardiomyopathy

Fetal Myocardium

Honeycomb Myocardium

Hypertrabeculation Syndrome

Left Ventricular Non-Compaction

Lvht

Non-Compaction Of The Left Ventricular Myocardium

Ventricular Noncompaction, Left

Non-Compaction Cardiomyopathy

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus RLF VGNC VGNC:64647
Bos taurus RLF VGNC VGNC:33990
Canis familiaris RLF VGNC VGNC:45604
Macaca mulatta RLF VGNC VGNC:76699
Rattus norvegicus RLF RGD RGD:1305297
Mus musculus RLF MGD MGI:1924705
Macaca fascicularis RLF NCBI NCBI:102125548
Others RLF NCBI