RLN2 - relaxin 2 Gene

中文名称：松弛素 2

种属: Homo sapiens

同用名: H2; RLXH2; H2-RLX; bA12D24.1.1; bA12D24.1.2

关于 RLN2

功能概要

该基因编码肽激素的松弛素亚家族和胰岛素超家族的成员。在人类中存在三个非等位基因松弛素基因。该基因编码多种蛋白质同种型，其中至少一种经过蛋白水解加工。这个过程产生松弛素 A 和 B 链，它们通过二硫键连接形成成熟的肽激素。这种激素在男性和女性生殖系统中发挥作用，最初因其在怀孕中的作用而闻名。这种蛋白质还在心血管系统中发挥更广泛的作用，包括调节血压和控制心率，动物模型的数据表明，这种蛋白质可能具有抗纤维化和心脏保护作用。[RefSeq 提供，2016 年 7 月]

This gene encodes a member of the relaxin subfamily and Insulin superfamily of peptide Hormones. In humans there are three non-allelic relaxin genes. This gene encodes multiple protein isoforms, at least one of which undergoes proteolytic processing. This processing generates relaxin A and B chains that are linked by disulfide bonds to form the mature peptide hormone. This hormone plays a role in the male and female reproductive systems and was initially noted for its role in pregnancy. This protein also plays broader roles in the cardiovascular system, including in the regulation of blood pressure and control of heart rate, and data from animal models shows that this protein may have anti-fibrotic and cardioprotective effects. [provided by RefSeq, Jul 2016]