2. Gene
  3. TGIF2 - TGFB induced factor homeobox 2 Gene

TGIF2 - TGFB induced factor homeobox 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：TGFB 诱导因子同源盒 2

种属: Homo sapiens

基因 ID: 60436 | 基因类型: protein coding

关于 TGIF2

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,573,464-36,593,950 (from NCBI)

This gene has 9 transcripts (splice variants), 162 orthologues and 12 paralogues. Ubiquitous expression in endometrium (RPKM 10.3), lymph node (RPKM 7.6) and 25 other tissues.

功能概要

由该基因编码的蛋白质是一种 DNA 结合同源框蛋白和一种转录抑制因子，它似乎通过将组蛋白去乙酰化酶募集到 TGF β 反应基因来抑制转录。该基因在某些卵巢癌中被放大和过度表达。可变剪接导致多个转录本变体。已在 1 号染色体上鉴定出一个相关的假基因。该基因与邻近的下游 C20orf24 (20 号染色体开放阅读框 24) 基因之间也存在通读转录。[RefSeq 提供，2010 年 12 月]

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor, which appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and over-expressed in some ovarian cancers. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. Read-through transcription also exists between this gene and the neighboring downstream C20orf24 (chromosome 20 open reading frame 24) gene. [provided by RefSeq, Dec 2010]

TGIF2 基因产物(4)

mRNA Protein Name
NM_001199513.2 NP_001186442.1 homeobox protein TGIF2
NM_001199514.2 NP_001186443.1 homeobox protein TGIF2
NM_001199515.2 NP_001186444.1 homeobox protein TGIF2
NM_021809.7 NP_068581.1 homeobox protein TGIF2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
22783022 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TGIF2 蛋白结构

Homeobox_KN

Homeobox_KN: Homeobox KN domain (36 - 75)

  • 0
  • 100
  • 200
  • 237 a.a.
蛋白主名 其他名称

homeobox protein TGIF2

5'-TG-3' interacting factor 2

关联疾病

疾病名称 别名
Holoprosencephaly 4

HPE4

Holoprosencephaly-4

Holoprosencephaly, Type 4
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14456 TGIF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS14457 TGIF2LX Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TGIF2 VGNC VGNC:35808
Mus musculus TGIF2 MGD MGI:1915299
Rattus norvegicus TGIF2 RGD RGD:1560115
Felis catus TGIF2 VGNC VGNC:66140
Canis familiaris TGIF2 VGNC VGNC:47314
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