2. Gene
  3. ABCE1 - ATP binding cassette subfamily E member 1 Gene

ABCE1 - ATP binding cassette subfamily E member 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ATP 结合盒亚家族 E 成员 1

种属: Homo sapiens

同用名: RLI; OABP; RLI1; ABC38; RNS4I; RNASEL1; RNASELI

基因 ID: 6059 | 基因类型: protein coding

关于 ABCE1

Cytogenetic location: 4q31.21 Genomic coordinates (GRCh38): 4:145,098,311-145,129,524 (from NCBI)

This gene has 10 transcripts (splice variants) and 227 orthologues. Ubiquitous expression in appendix (RPKM 18.4), lymph node (RPKM 18.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质是 ATP 结合盒 (ABC) 转运蛋白超家族的成员。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP、ALD、OABP、GCN20、White) 。这种蛋白质是 OABP 亚家族的成员。这种蛋白质也称为 RNase L 抑制剂，其功能是阻断核糖核酸酶 L 的活性。核糖核酸酶 L 的激活导致 2-5A/RNase L 系统中蛋白质合成的抑制，这是病毒干扰素作用的中心途径。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ABCE1 基因产物(2)

mRNA Protein Name
NM_001040876.2 NP_001035809.1 ATP-binding cassette sub-family E member 1
NM_002940.3 NP_002931.2 ATP-binding cassette sub-family E member 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP hydrolysis activity IDA
IDA: 通过直接分析推断
20122402 GOA
enables CTPase activity IDA
IDA: 通过直接分析推断
20122402 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
20122402 GOA
enables endoribonuclease inhibitor activity IDA
IDA: 通过直接分析推断
7539425 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
7539425 GOA
enables ribonucleoside triphosphate phosphatase activity IDA
IDA: 通过直接分析推断
20122402 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of endoribonuclease activity IDA
IDA: 通过直接分析推断
7539425 GOA
involved in rescue of stalled ribosome IDA
IDA: 通过直接分析推断
21448132 GOA
involved in ribosome disassembly IDA
IDA: 通过直接分析推断
20122402 GOA
involved in translational termination IDA
IDA: 通过直接分析推断
20122402 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11585831 GOA
is active in cytosolic ribosome IDA
IDA: 通过直接分析推断
20122402 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
11585831 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ABCE1 蛋白结构

RLI

RLI: Possible Fer4-like domain in RNase L inhibitor, RLI (7 - 37)

Fer4

Fer4: 4Fe-4S binding domain (49 - 70)

ABC_tran

ABC_tran: ABC transporter (102 - 244)

ABC_tran

ABC_tran: ABC transporter (367 - 490)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 599 a.a.
蛋白主名 其他名称

ATP-binding cassette sub-family E member 1

2'-5'-oligoadenylate-binding protein

ABCE1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ABCE1 P61221 EIF3J Homo sapiens O75822
Y2H Array
32296183
种属内
ABCE1 P61221 EIF3J Homo sapiens O75822
Y2H Prey Pooling
32296183
种属内
ABCE1 P61221 EIF3J Homo sapiens O75822
Anti Tag CoIP
35271311
种属间
ABCE1 P61221 gag Human immunodeficiency virus P03347-1
Pull Down
16275648
种属间
ABCE1 P61221 gag Human immunodeficiency virus P03347-1
Anti Tag CoIP
16275648
种属间: 跨种属相互作用 种属内: 同种属相互作用

ABCE1 抗体

目录号 产品名 应用 反应物种
HY-P81954 ABCE1 Antibody (YA1699) WB, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00072 ABCE1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ABCE1 VGNC VGNC:69581
Canis familiaris ABCE1 VGNC VGNC:37449
Bos taurus ABCE1 VGNC VGNC:25479
Mus musculus ABCE1 MGD MGI:1195458
Felis catus ABCE1 VGNC VGNC:68188
Rattus norvegicus ABCE1 RGD RGD:1305301
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