RPL18 - ribosomal protein L18 Gene

中文名称：核糖体蛋白 L18

种属: Homo sapiens

同用名: L18; DBA18

基因 ID: 6141 | 基因类型: protein coding

关于 RPL18

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,615,331-48,619,178 (from NCBI)

This gene has 16 transcripts (splice variants), 176 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 914.0), lymph node (RPKM 396.5) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码核糖体蛋白 L18E 家族的一个成员，该家族是 60S 亚基的一个组成部分。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L18E family of ribosomal proteins that is a component of the 60S subunit. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

RPL18 基因产物(2)

mRNA	Protein	Name
NM_000979.4	NP_000970.1	60S ribosomal protein L18 isoform 1
NM_001270490.2	NP_001257419.1	60S ribosomal protein L18 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	30021884	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	23636399	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cytoplasmic translation	IDA IDA: 通过直接分析推断	25957688	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of cytosolic large ribosomal subunit	IDA IDA: 通过直接分析推断	25957688	GOA
part of cytosolic large ribosomal subunit	IPI IPI: 通过物理相互作用推断	25901680	GOA
located in cytosolic ribosome	IDA IDA: 通过直接分析推断	23636399	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPL18 蛋白结构

Ribosomal_L27A

0
100
188 a.a.

蛋白主名

其他名称

60S ribosomal protein L18

large ribosomal subunit protein eL18

RPL18 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RPL18	Q07020	RPL4	Homo sapiens	P36578	Anti Tag CoIP	33961781

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Diamond-Blackfan Anemia 18

DBA18

Rpl18-Related Diamond-Blackfan Anemia

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Barber-Say Syndrome

Hypertrichosis, Atrophic Skin, Ectropion, And Macrostomia	Barber Say Syndrome
BBRSAY	Bss
Hypertrichosis Atrophic Skin Ectropion Macrostomia	Hypertrichosis-Atrophic Skin-Ectropion-Macrostomia Syndrome

Macrocytic Anemia

Anemia Macrocytic	Anemia, Macrocytic
Macrocytic Anaemia

Pierre Robin Syndrome

Pierre Robin Sequence	Glossoptosis, Micrognathia, And Cleft Palate
Pierre Robin Syndrome Skeletal Dysplasia Polydactyly	Pierre-Robin Syndrome
Isolated Pierre Robin Sequence	Isolated Pierre-Robin Syndrome
PRBNS	Robin Sequence
Robin Syndrome	Isolated Pierre Robin Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12169	RPL18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS12170	RPL18A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	RPL18	VGNC	VGNC:45714
Mus musculus	RPL18	MGD	MGI:98003
Rattus norvegicus	RPL18	RGD	RGD:621182
Bos taurus	RPL18	VGNC	VGNC:34111

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RPL18 - ribosomal protein L18 Gene

关于 RPL18

功能概要

RPL18 基因产物(2)

RPL18 蛋白结构

RPL18 蛋白互作信息

关联疾病

直系同源

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RPL18 - ribosomal protein L18 Gene

关于 RPL18

功能概要

RPL18 基因产物(2)

RPL18 蛋白结构

RPL18 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z