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  2. RPL36A - ribosomal protein L36a Gene

RPL36A - ribosomal protein L36a Gene

中文名称:核糖体蛋白 L36a

种属: Homo sapiens

同用名: L36A; L44L; MIG6; RPL44

基因 ID: 6173 | 基因类型: protein coding

关于 RPL36A

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:101,391,011-101,396,155 (from NCBI)

This gene has 10 transcripts (splice variants), 74 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 91.4), bone marrow (RPKM 73.7) and 25 other tissues.

功能概要

细胞质核糖体是催化蛋白质合成的细胞器,由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 60S 亚基的一个组成部分。该蛋白质与酵母核糖体蛋白 L44 具有序列相似性,属于核糖体蛋白 L44E (L36AE) 家族。尽管该基因被称为核糖体蛋白 L44 (RPL44) ,但其正式名称是核糖体蛋白 L36a (RPL36A) 。该基因与正式命名为类核糖体蛋白 L36a (RPL36AL) 的人类基因编码的蛋白质几乎相同;但是,它们是不同的基因。作为典型的编码核糖体蛋白的基因,该基因有多个经过处理的假基因分散在基因组中。自然发生的通读转录发生在该基因座和异质核核糖核蛋白 H2 (H') 基因之间。[RefSeq 提供,2011 年 1 月]

Cytoplasmic ribosomes, organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with yeast ribosomal protein L44, belongs to the L44E (L36AE) family of ribosomal proteins. Although this gene has been referred to as ribosomal protein L44 (RPL44), its official name is ribosomal protein L36a (RPL36A). This gene and the human gene officially named ribosomal protein L36a-like (RPL36AL) encode nearly identical proteins; however, they are distinct genes. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Naturally occurring read-through transcription occurs between this locus and the heterogeneous nuclear ribonucleoprotein H2 (H') gene. [provided by RefSeq, Jan 2011]

RPL36A 基因产物(1)

mRNA Protein Name
NM_021029.6 NP_066357.3 60S ribosomal protein L36a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24965446 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic translation IDA
IDA: 通过直接分析推断
25957688 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cytosolic large ribosomal subunit IDA
IDA: 通过直接分析推断
25957688 GOA
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPL36A 蛋白结构

Ribosomal_L44

Ribosomal_L44: Ribosomal protein L44 (17 - 94)

  • 0
  • 100
  • 106 a.a.
蛋白主名 其他名称

60S ribosomal protein L36a

60S ribosomal protein L44

RPL36A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPL36A P83881 AIDA Homo sapiens Q96BJ3 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RPL36A RGD RGD:1306640
Mus musculus RPL36A MGD MGI:1201789