2. Gene
  3. RPS5 - ribosomal protein S5 Gene

RPS5 - ribosomal protein S5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S5

种属: Homo sapiens

同用名: S5

基因 ID: 6193 | 基因类型: protein coding

关于 RPS5

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,387,269-58,394,804 (from NCBI)

This gene has 9 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 988.2), bone marrow (RPKM 469.7) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 40S 亚基的一个组成部分。该蛋白属于核糖体蛋白的 S7P 家族。它位于细胞质中。与邻近的正常组织相比，已观察到该基因在结直肠癌中的可变表达，尽管尚未发现表达水平与疾病严重程度之间的相关性。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供，2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7P family of ribosomal proteins. It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS5 基因产物(1)

mRNA Protein Name
NM_001009.4 NP_001000.2 40S ribosomal protein S5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA binding IDA
IDA: 通过直接分析推断
18464793 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24965446 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of translational fidelity IGI
IGI: 通过遗传相互作用推断
17901157 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: 通过直接分析推断
34516797 GOA
involved in translation IGI
IGI: 通过遗传相互作用推断
17901157 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: 通过直接分析推断
8706699 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
18809582 GOA
part of small-subunit processome IDA
IDA: 通过直接分析推断
34516797 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS5 蛋白结构

Ribosomal_S7

Ribosomal_S7: Ribosomal protein S7p/S5e (50 - 204)

  • 0
  • 100
  • 204 a.a.
蛋白主名 其他名称

40S ribosomal protein S5

small ribosomal subunit protein uS7

RPS5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPS5 P46782 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
种属内
RPS5 P46782 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
种属内
RPS5 P46782 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
种属内
RPS5 P46782 ATXN1 Homo sapiens P54253
Y2H Array
32814053
种属内
RPS5 P46782 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
种属内
RPS5 P46782 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 14

RP14

Retinitis Pigmentosa Juvenile Tulp1-Related

Retinitis Pigmentosa-14

Retinitis Pigmentosa, Type 14
Erythroleukemia
Axonal Neuropathy
Anterior Segment Dysgenesis 5

Anterior Segment Dysgenesis 5, Multiple Subtypes

ASGD5

Dysgenesis, Anterior Segment, Type 5, Multiple Subtypes
Long Qt Syndrome 1

Romano-Ward Syndrome

LQT1

Ward-Romano Syndrome

Rws

Ventricular Fibrillation With Prolonged Qt Interval

Wrs

Long Qt Syndrome 1, Acquired, Susceptibility To

Long Qt Syndrome 1, Acquired

Romano-Ward Long Qt Syndrome

Long Qt Syndrome Type 1

Long Qt Syndrome-1

Acquired Susceptibility To Long Qt Syndrome 1

Qt Syndrome, Long, Type 1
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12246 RPS5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus RPS5 VGNC VGNC:64753
Bos taurus RPS5 VGNC VGNC:34139
Macaca mulatta RPS5 VGNC VGNC:103858
Rattus norvegicus RPS5 RGD RGD:3601
Mus musculus RPS5 MGD MGI:1097682
Canis familiaris RPS5 VGNC VGNC:45737
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