2. Gene
  3. RPS8 - ribosomal protein S8 Gene

RPS8 - ribosomal protein S8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核糖体蛋白 S8

种属: Homo sapiens

同用名: S8

基因 ID: 6202 | 基因类型: protein coding

关于 RPS8

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:44,775,540-44,778,779 (from NCBI)

This gene has 8 transcripts (splice variants) and 233 orthologues. Ubiquitous expression in ovary (RPKM 2095.9), bone marrow (RPKM 913.3) and 25 other tissues.

功能概要

核糖体是催化蛋白质合成的细胞器，由一个小的 40S 亚基和一个大的 60S 亚基组成。这些亚基一起由 4 种 RNA 和大约 80 种结构不同的蛋白质组成。该基因编码的核糖体蛋白是 40S 亚基的一个组成部分。该蛋白属于核糖体蛋白的 S8E 家族。它位于细胞质中。与匹配的正常结肠粘膜相比，已观察到该基因在结直肠肿瘤和结肠息肉中的表达增加。该基因与小核仁 RNA 基因 U38A、U38B、U39 和 U40 共转录，分别位于其第四、第五、第一和第二个内含子。作为典型的编码核糖体蛋白的基因，该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供，2008 年 7 月]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS8 基因产物(1)

mRNA Protein Name
NM_001012.2 NP_001003.1 40S ribosomal protein S8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
30021884 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ribosomal small subunit biogenesis IDA
IDA: 通过直接分析推断
34516797 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosolic ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: 通过直接分析推断
8706699 GOA
part of ribonucleoprotein complex IDA
IDA: 通过直接分析推断
17289661 GOA
part of small-subunit processome IDA
IDA: 通过直接分析推断
34516797 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPS8 蛋白结构

Ribosomal_S8e

Ribosomal_S8e: Ribosomal protein S8e (1 - 190)

  • 0
  • 100
  • 208 a.a.
蛋白主名 其他名称

40S ribosomal protein S8

OK/SW-cl.83

RPS8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RPS8 P62241 DLG2 Homo sapiens Q15700
Y2H Prey Pooling
32296183
种属内
RPS8 P62241 DLG2 Homo sapiens Q15700
Validated Y2H
32296183
种属内
RPS8 P62241 DLG2 Homo sapiens Q15700
Y2H Array
32296183
种属内
RPS8 P62241 DLG3 Homo sapiens Q92796
Y2H Prey Pooling
32296183
种属内
RPS8 P62241 DLG3 Homo sapiens Q92796
Validated Y2H
32296183
种属内
RPS8 P62241 DLG3 Homo sapiens Q92796
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

RPS8 抗体

目录号 产品名 应用 反应物种
HY-P83475 RPS8 Antibody (YA3220) WB, ICC/IF, IP Human, Mouse, Rat, Hamster

关联疾病

疾病名称 别名
Theileriasis

Theileriosis

Infection By Theileria
Babesiosis

Babesiasis

Infection By Babesia

Piroplasmosis

Human Babesiosis

Babesia Parasite Infection

Piroplasma Infection
Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12270 RPS8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RPS8 VGNC VGNC:34151
Rattus norvegicus RPS8 RGD RGD:61910
Macaca mulatta RPS8 VGNC VGNC:106490
Mus musculus RPS8 MGD MGI:98166
Canis familiaris RPS8 VGNC VGNC:103702
Felis catus RPS8 VGNC VGNC:107615
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