1. Gene
  2. RPS26 - ribosomal protein S26 Gene

RPS26 - ribosomal protein S26 Gene

中文名称:核糖体蛋白 S26

种属: Homo sapiens

同用名: S26; eS26; DBA10

基因 ID: 6231 | 基因类型: protein coding

关于 RPS26

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:56,041,918-56,044,697 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 419.1), adrenal (RPKM 280.6) and 25 other tissues.

功能概要

该基因编码的核糖体蛋白是 40S 亚基的一个组成部分。该蛋白属于核糖体蛋白 S26E 家族。在 Diamond-Blackfan 贫血 10 中发现了该基因的突变。该基因有多个经过处理的假基因分散在基因组中。[RefSeq 提供,2017 年 8 月]

This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S26E family of ribosomal proteins. Mutations in this gene are found in Diamond-Blackfan anemia 10. There are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Aug 2017]

RPS26 基因产物(1)

mRNA Protein Name
NM_001029.5 NP_001020.2 40S ribosomal protein S26
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA binding IDA
IDA: 通过直接分析推断
15716004 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables structural constituent of ribosome IDA
IDA: 通过直接分析推断
23636399 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytoplasmic translation IDA
IDA: 通过直接分析推断
25957688 GOA
involved in negative regulation of RNA splicing IDA
IDA: 通过直接分析推断
15716004 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of cytosolic small ribosomal subunit IDA
IDA: 通过直接分析推断
8706699 GOA
located in ribosome IDA
IDA: 通过直接分析推断
25957688 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RPS26 蛋白结构

Ribosomal_S26e

Ribosomal_S26e: Ribosomal protein S26e (1 - 105)

  • 0
  • 100
  • 115 a.a.
蛋白主名 其他名称

40S ribosomal protein S26

small ribosomal subunit protein eS26

RPS26 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RPS26 P62854 TSR2 Homo sapiens Q969E8
Y2H Pooling
16189514
Intra RPS26 P62854 TSR2 Homo sapiens Q969E8
Validated Y2H
32296183
Intra RPS26 P62854 TSR2 Homo sapiens Q969E8
Y2H Array
25416956
Intra RPS26 P62854 TSR2 Homo sapiens Q969E8
Y2H Array
32296183
Intra RPS26 P62854 TSR2 Homo sapiens Q969E8
Y2H Prey Pooling
32296183
Intra RPS26 P62854 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra RPS26 P62854 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diamond-Blackfan Anemia 10

DBA10

Rps26-Related Diamond-Blackfan Anemia

Anemia, Diamond-Blackfan, Type 10

Diamond-Blackfan Anemia 15 With Mandibulofacial Dysostosis

DBA15

Diamond Blackfan Anemia 15 With Mandibulofacial Dysostosis

Diamond-Blackfan Anemia 15, With Mandibulofacial Dysostosis

Diamond-Blackfan Anemia With Microtia And Cleft Palate

Anemia, Diamond Blackfan, Type 15 With Mandibulofacial Dysostosis

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome

Pure Red-Cell Aplasia

Pure Red Cell Aplasia

Primary Red Cell Aplasia

Red Cell Hypoplasia

Prca

Red-Cell Aplasia Pure

Red-Cell Aplasia, Pure

Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia

Macrocytic Anemia

Anemia Macrocytic

Anemia, Macrocytic

Macrocytic Anaemia

Klippel-Feil Syndrome

Cervical Vertebral Fusion

Congenital Dystrophia Brevicollis

Cervical Fusion Syndrome

Klippel-Feil Deformity

Autosomal Dominant Klippel-Feil Syndrome

Congenital Synostosis Of Cervical Vertebrae

Klippel-Feil And Turner Syndrome

Klippel-Feil Deformity, Deafness And Facial Asymmetry

Klippel Feil Syndrome

Cervical Vertebral Fusion Syndrome

Dystrophia Brevicollis Congenita

Fusion Of Cervical Vertebrae

Kfs

Klippel-Feil Sequence

Vertebral Cervical Fusion Syndrome

Klippel-Feil Syndrome, Autosomal Dominant

Klippel-Feil Malformation

Isolated Klippel-Feil Syndrome

Retinitis Pigmentosa 26

RP26

Retinitis Pigmentosa-26

Retinitis Pigmentosa, Type 26

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome

Shwachman Syndrome

Shwachman-Bodian-Diamond Syndrome

Sds

Pancreatic Insufficiency And Bone Marrow Dysfunction

Shwachman-Bodian Syndrome

SDS1

Lipomatosis Of Pancreas, Congenital

Congenital Lipomatosis Of Pancreas

Shwachman-Diamond Type Metaphyseal Dysplasia

Metaphyseal Chondrodysplasia, Shwachman Type

Shwachman-Diamond-Oski Syndrome

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome

Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate

Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RPS26 RGD RGD:2319323
Canis familiaris RPS26 VGNC VGNC:54539
Mus musculus RPS26 MGD MGI:1351628