1. Gene
  2. S100A8 - S100 calcium binding protein A8 Gene

S100A8 - S100 calcium binding protein A8 Gene

中文名称:S100 钙结合蛋白 A8

种属: Homo sapiens

同用名: P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG; S100-A8

基因 ID: 6279 | 基因类型: protein coding

关于 S100A8

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,390,032-153,422,583 (from NCBI)

This gene has 3 transcripts (splice variants), 346 orthologues and 21 paralogues. Biased expression in bone marrow (RPKM 3778.8), esophagus (RPKM 2115.4) and 1 other tissue.

功能概要

由该基因编码的蛋白质是包含 2 个 EF 手钙结合基序的 S100 蛋白质家族的成员。 S100 蛋白定位于多种细胞的细胞质和/或细胞核,并参与许多细胞过程的调节,例如细胞周期进程和分化。 S100 基因包括至少 13 个成员,它们成簇地位于染色体 1q21 上。这种蛋白质可能在抑制酪蛋白激酶和作为细胞因子方面发挥作用。这种蛋白质表达的改变与囊性纤维化疾病有关。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2016 年 1 月]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of Casein Kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

S100A8 基因产物(5)

mRNA Protein Name
NM_001319196.1 NP_001306125.1 protein S100-A8 isoform a
NM_001319197.1 NP_001306126.1 protein S100-A8 isoform b
NM_001319198.2 NP_001306127.1 protein S100-A8 isoform c
NM_001319201.2 NP_001306130.1 protein S100-A8 isoform d
NM_002964.5 NP_002955.2 protein S100-A8 isoform d
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9867828 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
19935772 GOA
involved in autophagy IDA
IDA: 通过直接分析推断
19935772 GOA
involved in leukocyte migration involved in inflammatory response IDA
IDA: 通过直接分析推断
12626582 GOA
involved in neutrophil aggregation IDA
IDA: 通过直接分析推断
12626582 GOA
involved in neutrophil chemotaxis IDA
IDA: 通过直接分析推断
12626582 GOA
involved in peptidyl-cysteine S-nitrosylation IMP
IMP: 通过突变表型推断
25417112 GOA
involved in positive regulation of inflammatory response IDA
IDA: 通过直接分析推断
12626582 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway IDA
IDA: 通过直接分析推断
19935772 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calprotectin complex IPI
IPI: 通过物理相互作用推断
25597447 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
21805676 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

S100A8 蛋白结构

S_100

S_100: S-100/ICaBP type calcium binding domain (5 - 48)

  • 0
  • 93 a.a.
蛋白主名 其他名称

protein S100-A8

calgranulin A

S100A8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
S100A8 P05109 S100A9 Homo sapiens P06702
Anti Bait CoIP
25417112
种属内
S100A8 P05109 S100A9 Homo sapiens P06702
Anti Tag CoIP
25417112
种属内
S100A8 P05109 S100A9 Homo sapiens P06702
Y2H
9867828
种属内
S100A8 P05109 TRPM4 Homo sapiens Q8TD43
FPS
31837246
种属内
S100A8 P05109 GAPDH Homo sapiens P04406
Anti Tag CoIP
25417112
种属内
S100A8 P05109 GAPDH Homo sapiens P04406
Anti Bait CoIP
25417112
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 S100A8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70531 S100A8 Protein, Human (C-His) P05109 (M1-E93) ≥95%
HY-P71076 S100A8-S100A9 Heterodimer Protein, Human (His) P05109 (M1-E93)(S100A8) & P06702 (T2-P114) (S100A9) ≥95%
HY-P76586 S100A8 Protein, Human (sf9, His) P05109 (M1-E93) ≥95%
HY-P70531A S100A8 Protein, Human (N-His) P05109 (M1-E93) ≥95%

关联疾病

疾病名称 别名
Peptic Ulcer Disease

Peptic Ulcer

Acute Peptic Ulcer With Hemorrhage

Acute Peptic Ulcer With Hemorrhage And Perforation

Acute Peptic Ulcer Without Hemorrhage And Without Perforation

Duodenal Ulcer

Stress Ulcer

Curling Ulcer

Stress Ulcer Of Stomach

Curling'S Ulcers

Duodenal Ulcer Disease

Duodenal Ulcers

Duodenal Peptic Ulcer

Atrophic Gastritis

Gastritis, Atrophic

Gastric Atrophy

Gastritis Atrophic

Gastritis

Acute Gastric Mucosal Erosion

Erosive Gastritis

Erosive Gastropathy

Gastritis Erosive

Idiopathic Erosive/Hemorrhagic Gastritis

Inflammation Of Gastric Mucosa

Gastroduodenitis

Gastritis Nos

Noninfectious Gastroenteritis

Nonbacterial Gastroenteritis Of Infant

Acute Gastric Infection

Acute Simple Gastritis

Chronic Antral Gastritis

Chronic Fundal Gastritis

Chronic Simple Gastritis

Acute Gastroduodenitis

Acute Antral Gastritis

Acute Erosive Gastritis

Bile Reflux Gastritis

Gastritis Due To Biliary Reflux

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Duodenum Disease

Duodenal Diseases

Duodenal Disease

Duodenum Disorder

Gastrointestinal System Disease

Gastrointestinal Disease

Gastrointestinal Diseases

Alimentary System Disease

Digestive System Disorder

Gastroenteropathy

Gastrointestinal Disorder

Git Disease

Digestive System Diseases

Gastrointestinal Disorders

Digestive System Disease

Digestive System Disorders

Peptic Ulcer Perforation

Perforated Peptic Ulcer

Acute Peptic Ulcer With Perforation

Peptic Ulcer With Perforation

Duodenitis

Hemorrhagic Duodenitis

Acute Enteritis Of The Mouse Intestinal Tract

Nonspecific Duodenitis

Inflammation Of Duodenum

Dodecadactylitis

Duodenal Inflammation

Peptic Duodenitis

Gastric Lymphoma

Familial Primary Gastric Lymphoma

Lymphoma Of The Stomach

Primary Gastric Lymphoma

Gastric Ulcer

Stomach Ulcer

Acute Gastric Ulcer With Haemorrhage And Perforation

Acute Gastric Ulcer With Hemorrhage And Obstruction

Acute Gastric Ulcer With Hemorrhage And Perforation

Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction

Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction

Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction

Acute Gastric Ulcer With Hemorrhage, With Obstruction

Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction

Acute Gastric Ulcer With Perforation

Acute Gastric Ulcer With Perforation And Obstruction

Acute Gastric Ulcer With Perforation, With Obstruction

Acute Gastric Ulcer Without Hemorrhage And Without Perforation

Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction

Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction

Bleeding Acute Gastric Ulcer

Chronic Gastric Ulcer Without Hemorrhage And Without Perforation

Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction

Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction

Gastric Ulcers

Cushings Ulcer

Cushing'S Ulcer Of Stomach

Peptic Ulcer Of Stomach

Mucosal Defect Of The Stomach

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma

Crohn'S Disease

Crohn Disease

Pediatric Crohn'S Disease

Regional Enteritis

Crohn'S Disease Of Large Bowel

Granulomatous Colitis

Enteritis, Granulomatous

Enteritis

Crohn'S Disease Of Colon

Colitis, Granulomatous

Crohn'S Enteritis

Enteritis, Regional

Ileitis

Adenoviral Enteritis

Acute Gastroenteropathy Due To Norwalk Agent

Viral Gastroenteritis Due To Norwalk Agent

Winter Vomiting

Epidemic Winter Vomiting Disease

Small Round Structured Virus Enteritis

Epidemic Vomiting Syndrome

Epidemic Vomiting

Epidemic Nausea

Epidemic Viral Gastroenteritis Due To Norwalk Virus

Noroviral Enteritis

Crohn Disease Nos

Crohns

Cd - [Crohn'S Disease]

Regional Enteritis Of Bowel

Crohn'S Regional Enteritis

Cobble-Stone Appearance Of Intestine

Intestinal Ulcer And Erosion Due To Crohn Disease

Granulomatous Enteritis

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis

Juvenile Chronic Polyarthritis

Monarticular Juvenile Rheumatoid Arthritis

Pauciarticular Juvenile Arthritis

Still'S Disease

Systemic Juvenile Rheumatoid Arthritis

Juvenile Chronic Arthritis

Acute Juvenile Rheumatoid Arthritis

Pauciarticular Onset Juvenile Chronic Arthritis

Arthritis, Juvenile Rheumatoid

Jia

Jra

Juvenile Ra

Arthritis Juvenile Rheumatoid

Stills Disease

Juvenile Arthritis

Acute Polyarticular Juvenile Rheumatoid Arthritis

Pauciarticular Juvenile Rheumatoid Arthritis

Rheumatoid Arthritis, Systemic Juvenile

Gastric Adenocarcinoma

Adenocarcinoma Of Stomach

Stomach Adenocarcinoma

Adenocarcinoma Gastric

Intestinal Type Adenocarcinoma Of Unspecified Site

Diffuse Type Adenocarcinoma Of Unspecified Site

Cardia Cancer

Ca Cardia - Stomach

Malignant Neoplasm Of Cardia Of Stomach

Microinvasive Gastric Cancer

Early Gastric Cancer

Surface Gastric Cancer

Psoriasis
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Cholesteatoma Of Middle Ear

Cholesteatoma

Epidermosis Of Ear

Epidermosis Of Middle Ear

Middle Ear Cholesteatoma

Cholesteatoma Of Middle Ear And Mastoid

Cholesteatoma Of Middle Ear And/Or Mastoid

Cholesteatoma Of The Middle Ear

Congenital Cholesteatoma

Primary Acquired Cholesteatoma

Secondary Acquired Cholesteatoma

Cholesteatoma Middle Ear

Cholesteatoma, Middle Ear

Cholesterolosis Of Middle Ear

Cholesterosis Of Ear

Cholesterosis Of Middle Ear

Cholesteatoma Nos

Epidermoid Cholesteatoma

Middle Ear Granuloma

Rosacea

Erythematotelangiectatic Rosacea

Papulopustular Rosacea

Phymatous Rosacea

Acne Roscea

Acne, Erythematosa

Granulomatous Rosacea

Ocular Rosacea

Acne Rosacea

Hypertrophic Rosacea

Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Esophagus Melanoma

Melanoma Of Esophagus

Melanoma Of Oesophagus

Oesophagus Melanoma

Esophageal Melanoma

Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]

Appendicitis

Acute Appendicitis

Acute Appendicitis With Generalized Peritonitis

Acute Appendicitis Nos

Acute Appendicitis With Peritoneal Abscess

Appendiceal Inflammation

Appendicitis, Unqualified

Acute Appendix Inflammation

Acute Appendicitis With Diffuse Peritonitis Following Rupture Or Perforation

Acute Appendicitis With Free Peritonitis

Acute Appendicitis With Free Perforation To The Abdominal Cavity

Perforated Appendix With Generalised Peritonitis

Appendicitis With Perforation And Free Pus In The Peritoneal Cavity

Perforated Appendix With Localised Peritonitis

Acute Appendicitis With Contained Perforation To A Localised Abscess

Acute Appendicitis With Localised Peritonitis With Rupture Or Perforation

Acute Appendicitis With Localised Peritonitis Without Rupture Or Perforation

Acute Appendicitis With Perforation And Contained Peritonitis Into An Abscess

Appendicitis With Abscess

Appendicitis With Peritoneal Abscess

Ruptured Appendix Nos

Acute Appendicitis With No Perforation Or Abscess And No Visible Pus

Acute Appendicitis With No Specification If Perforated Or Not

Acute Appendicitis With Phlegmone

Cholecystitis

Acute Cholecystitis

Chronic Cholecystitis

Acalculous Cholecystitis

Acute And Chronic Cholecystitis

Acute On Chronic Cholecystitis

Gallstone Cholecystitis

Cholecystitis, Acute

Calculus Of Gallbladder With Cholecystitis

Gallbladder Inflammation

Acute Cholecystitis Infection

Acute Acalculous Cholecystitis

Chronic Acalculous Cholecystitis

Nonfunctioning Gallbladder

Fungal Gastritis
Peptic Esophagitis

Reflux Esophagitis

Peptic Reflux Disease

Reflux Oesophagitis

Esophagitis, Peptic

Gastro-Esophageal Reflux Disease With Esophagitis

Squamous Blepharitis
Gastroesophageal Reflux

Gastroesophageal Reflux Disease

Gerd

GER

Gastroesophageal Reflux, Pediatric

Acid Reflux

Gastresophageal Reflux

Gastro-Esophageal Reflux

Gerd - Gastro-Esophageal Reflux Disease

Thrombocytopenic Purpura, Autoimmune

Idiopathic Thrombocytopenic Purpura

Autoimmune Thrombocytopenic Purpura

Immune Thrombocytopenic Purpura

Itp

Idiopathic Purpura

AITP

Ideopath Thrombocytopenic Pur

Primary Thrombocytopenic Purpura

Werlhof'S Disease

Thrombocytopenic Purpura Autoimmune

Purpura Thrombocytopenic Idiopathic

Purpura, Thrombocytopenic, Idiopathic

Autoimmune Thrombocytopenia

Thrombocytopenia Due To Platelet Alloimmunization

Idiopathic Thrombocytopenia

Idiopathic Thrombocytopenia Purpura

Frank'S Essential Thrombocytopenia

Itp - [Idiopathic Thrombocytopenia Purpura]

Werlhof Disease

Primary Autoimmune Thrombocytopenic Purpura

Haemorrhagic Purpura

Essential Thrombocytopenia

Purpura Haemorrhagica

Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung

Onchocerciasis

Infection By Onchocerca Volvulus

River Blindness

Onchocerca Volvulus Infection

Volvulosis

Robles' Disease

Onchocerciasis, Ocular

Robles Disease

Onchocercosis

Blinding Filariasis

Robles

Onchocerca Infestation

Craw-Craw

Renal Infectious Disease
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Granulomatous Gastritis
Barrett Esophagus

Barrett'S Esophagus

Barrett Esophagus/Esophageal Adenocarcinoma

Barrett Metaplasia

Barrett'S Ulcer Of Esophagus

Ulcerative Esophagitis

Barrett'S Esophagus With Esophagitis

Barrett'S Oesophagus

Barretts Syndrome

Barrett Syndrome

BE

Peptic Ulcer Of Esophagus

Adenocarcinoma Of Esophagus

Autoimmune Gastritis
Marginal Zone B-Cell Lymphoma

Marginal Zone Lymphoma

Mzl

Mucosa-Associated Lymphoid Tissue Lymphoma

Bile Reflux
Larynx Squamous Papilloma

Laryngeal Squamous Cell Papilloma

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Diffuse Gastric And Lobular Breast Cancer Syndrome

Hereditary Diffuse Gastric Cancer

HDGC

LBC

Familial Diffuse Gastric Cancer

Fdgc

Hereditary Diffuse Gastric Adenocarcinoma

Breast Cancer, Lobular

Gastric Cancer, Familial Diffuse, And Cleft Lip With Or Without Cleft Palate

DGLBC

Gastric Cancer, Hereditary Diffuse

Gastric Cancer, Familial Diffuse Breast Cancer, Lobular

Diffuse Gastric And Lobular Breast Cancer Syndrome With Or Without Cleft Lip And/Or Palate

E-Cadherin-Associated Hereditary Gastric Cancer

Familial Diffuse Cancer Of Stomach

Hereditary Diffuse Cancer Of Stomach

Gastric Cancer Familial Diffuse

Gastric Cancer Familial Diffuse And Cleft Lip With Or Without Cleft Palate

Cancer, Gastric, Hereditary Diffuse

Spondylarthropathy

Spondylarthropathies

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus S100A8 VGNC VGNC:64842
Rattus norvegicus S100A8 RGD RGD:620265
Canis familiaris S100A8 VGNC VGNC:45833
Bos taurus S100A8 VGNC VGNC:34246
Macaca mulatta S100A8 VGNC VGNC:100128
Mus musculus S100A8 MGD MGI:88244
Others S100A8 NCBI