SERPINB3 - serpin family B member 3 Gene

中文名称：serpin 家族 B 成员 3

种属: Homo sapiens

同用名: SCC; T4-A; SCCA1; SSCA1; SCCA-1; HsT1196; SCCA-PD

基因 ID: 6317 | 基因类型: protein coding

关于 SERPINB3

Cytogenetic location: 18q21.33 Genomic coordinates (GRCh38): 18:63,655,197-63,661,893 (from NCBI)

This gene has 2 transcripts (splice variants), 223 orthologues and 36 paralogues. Restricted expression toward esophagus (RPKM 424.4).

功能概要

启用半胱氨酸型内肽酶抑制剂活性；蛋白酶结合活性；和病毒受体活性。参与多个过程，包括自分泌信号；旁分泌信号；和调节细胞蛋白质代谢过程。位于细胞质囊泡中；细胞外外泌体；和核。 [由基因组资源联盟提供，2022 年 4 月]

Enables cysteine-type endopeptidase inhibitor activity; protease binding activity; and virus receptor activity. Involved in several processes, including autocrine signaling; paracrine signaling; and regulation of cellular protein metabolic process. Located in cytoplasmic vesicle; extracellular exosome; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

SERPINB3 基因产物(1)

mRNA	Protein	Name
NM_006919.3	NP_008850.1	serpin B3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cysteine-type endopeptidase inhibitor activity	IMP IMP: 通过突变表型推断	21383048	GOA
enables protease binding	IPI IPI: 通过物理相互作用推断	21383048	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA
enables virus receptor activity	IDA IDA: 通过直接分析推断	12975381	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in autocrine signaling	IMP IMP: 通过突变表型推断	20527027	GOA
involved in negative regulation of JUN kinase activity	IMP IMP: 通过突变表型推断	21383048	GOA
involved in negative regulation of catalytic activity	IDA IDA: 通过直接分析推断	10956412	GOA
involved in negative regulation of endopeptidase activity	IMP IMP: 通过突变表型推断	21383048	GOA
involved in negative regulation of peptidase activity	IDA IDA: 通过直接分析推断	12949073	GOA
involved in negative regulation of proteolysis	IDA IDA: 通过直接分析推断	12975381	GOA
involved in paracrine signaling	IMP IMP: 通过突变表型推断	20527027	GOA
involved in positive regulation of cell migration	IMP IMP: 通过突变表型推断	20527027	GOA
involved in positive regulation of cell population proliferation	IMP IMP: 通过突变表型推断	20527027	GOA
involved in positive regulation of endopeptidase activity	IDA IDA: 通过直接分析推断	20527027	GOA
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	20527027	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	20527027	GOA
located in cytoplasmic vesicle	IDA IDA: 通过直接分析推断	21383048	GOA
located in extracellular exosome	IDA IDA: 通过直接分析推断	21557262	GOA
located in nucleus	IDA IDA: 通过直接分析推断	20527027	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SERPINB3 蛋白结构

Serpin

0
100
200
300
390 a.a.

蛋白主名

其他名称

serpin B3

protein T4-A

SERPINB3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SERPINB3	P29508	SERPINB4	Homo sapiens	P48594	Anti Tag CoIP	33961781
种属内	SERPINB3	P29508	SERPINB4	Homo sapiens	P48594	Anti Tag CoIP	28514442

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SERPINB3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71142	Serpin B3 Protein, Human (HEK293, His)	P29508 (M1-P390)	≥95%

关联疾病

疾病名称

别名

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Cervical Squamous Cell Carcinoma

Squamous Cell Carcinoma Of The Cervix Uteri

Squamous Cell Carcinoma Of Cervix

Otomycosis

Singapore Ear

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Cervical Cancer

Cervical Cancer, Somatic	Neoplasm Of Uterine Cervix
Cervix Cancer	Uterine Cervical Neoplasm
Cervical Neoplasm	Cervix Uteri Cancer
Tumor Of The Cervix Uteri	CERCA
Uterine Cervical Cancer	Neoplasms Cervical
Uterine Cervical Neoplasms	Cervical Cancers
Cancer, Cervical, Somatic	Malignant Tumor Of Cervix
Cervix Carcinoma

Psoriasis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS12711	SERPINB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SERPINB3	RGD	RGD:1549766

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SERPINB3 - serpin family B member 3 Gene

关于 SERPINB3

功能概要

SERPINB3 基因产物(1)

SERPINB3 蛋白结构

SERPINB3 蛋白互作信息

重组 SERPINB3 蛋白

关联疾病

直系同源

热门区域

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SERPINB3 - serpin family B member 3 Gene

关于 SERPINB3

功能概要

SERPINB3 基因产物(1)

SERPINB3 蛋白结构

SERPINB3 蛋白互作信息

重组 SERPINB3 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z