CCL13 - C-C motif chemokine ligand 13 Gene

中文名称：CC 基序趋化因子配体 13

种属: Homo sapiens

同用名: NCC1; CKb10; MCP-4; NCC-1; SCYL1; SCYA13

基因 ID: 6357 | 基因类型: protein coding

关于 CCL13

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:34,356,480-34,358,610 (from NCBI)

This gene has 2 transcripts (splice variants), 79 orthologues and 25 paralogues. Broad expression in colon (RPKM 14.2), small intestine (RPKM 11.9) and 14 other tissues.

功能概要

这种抗菌基因是聚集在 17 号染色体 q 臂上的几种 Cys-Cys (CC) 细胞因子基因之一。细胞因子是参与免疫调节和炎症过程的分泌蛋白家族。 CC 细胞因子是以两个相邻的半胱氨酸为特征的蛋白质。由该基因编码的细胞因子对单核细胞、淋巴细胞、嗜碱性粒细胞和嗜酸性粒细胞显示趋化活性，但对中性粒细胞不显示。这种趋化因子在炎症期间的白细胞积累中起作用。它还可能参与动脉粥样硬化期间单核细胞向动脉壁的募集。[RefSeq 提供，2014 年 9 月]

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]

CCL13 基因产物(1)

mRNA	Protein	Name
NM_005408.3	NP_005399.1	C-C motif chemokine 13 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chemokine activity	IDA IDA: 通过直接分析推断	10072545	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28381538	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: 通过直接分析推断	12949249	GOA
involved in cytoskeleton organization	IDA IDA: 通过直接分析推断	10072545	GOA
involved in eosinophil chemotaxis	IDA IDA: 通过直接分析推断	10072545	GOA
involved in killing of cells of another organism	IDA IDA: 通过直接分析推断	12949249	GOA
involved in regulation of cell shape	IDA IDA: 通过直接分析推断	10072545	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCL13 蛋白结构

IL8

0
98 a.a.

蛋白主名

其他名称

C-C motif chemokine 13

CK-beta-10

CCL13 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCL13	Q99616	XCL1	Homo sapiens	P47992	Filter Binding	28381538
种属内	CCL13	Q99616	PF4	Homo sapiens	P02776	SPR	28381538
种属内	CCL13	Q99616	CCL5	Homo sapiens	P13501	SPR	28381538
种属内	CCL13	Q99616	CCL5	Homo sapiens	P13501	Filter Binding	28381538
种属内	CCL13	Q99616	CXCL11	Homo sapiens	O14625	Filter Binding	28381538
种属内	CCL13	Q99616	CXCL12	Homo sapiens	P48061	SPR	28381538
种属内	CCL13	Q99616	CXCL12	Homo sapiens	P48061	Filter Binding	28381538
种属内	CCL13	Q99616	CCL26	Homo sapiens	Q9Y258	Filter Binding	28381538
种属内	CCL13	Q99616	CXCL10	Homo sapiens	P02778	Filter Binding	28381538
种属内	CCL13	Q99616	CCL21	Homo sapiens	O00585	Filter Binding	28381538

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CCL13 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7245	MCP-4/CCL13 Protein, Human	Q99616 (Q24-T98)	≥95%

关联疾病

疾病名称

别名

Mansonelliasis

Mansonellosis	Mansonella Perstans Infections
Mansonella Infestation

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Allergic Disease

Hypersensitivity	Allergic Hypersensitivity Disease
Allergic Condition	Allergic Reaction
Allergic Disposition

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02082	CCL13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CCL13	VGNC	VGNC:70696
Mus musculus	CCL13	MGD	MGI:98259
Rattus norvegicus	CCL13	RGD	RGD:1309255
Others	CCL13	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCL13 - C-C motif chemokine ligand 13 Gene

关于 CCL13

功能概要

CCL13 基因产物(1)

CCL13 蛋白结构

CCL13 蛋白互作信息

重组 CCL13 蛋白

关联疾病

直系同源

热门区域

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CCL13 - C-C motif chemokine ligand 13 Gene

关于 CCL13

功能概要

CCL13 基因产物(1)

CCL13 蛋白结构

CCL13 蛋白互作信息

重组 CCL13 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z