CCL24 - C-C motif chemokine ligand 24 Gene

中文名称：CC 基序趋化因子配体 24

种属: Homo sapiens

同用名: Ckb-6; MPIF2; MPIF-2; SCYA24

基因 ID: 6369 | 基因类型: protein coding

关于 CCL24

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:75,810,825-75,823,372 (from NCBI)

This gene has 2 transcripts (splice variants), 100 orthologues and 25 paralogues. Biased expression in small intestine (RPKM 18.6), colon (RPKM 9.1) and 8 other tissues.

功能概要

该基因属于小细胞因子 CC 基因亚家族。细胞因子是参与免疫调节和炎症过程的分泌蛋白家族。 CC 细胞因子是以两个相邻的半胱氨酸为特征的蛋白质。由该基因编码的细胞因子对静息 T 淋巴细胞显示趋化活性，对嗜中性粒细胞具有最小活性，对单核细胞和活化 T 淋巴细胞呈阴性。这种蛋白质还具有抗菌活性，对肺炎链球菌、金黄色葡萄球菌、不可分型流感嗜血杆菌和铜绿假单胞菌显示出抗菌作用。最后，该蛋白质是多能造血祖细胞系集落形成的强抑制剂。[RefSeq 提供，2020 年 7 月]

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. This protein also has antimicrobial activity, displaying an Antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. Finally, the protein is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2020]

CCL24 基因产物(2)

mRNA	Protein	Name
NM_001371193.1	NP_001358122.1	C-C motif chemokine 24 precursor
NM_002991.3	NP_002982.2	C-C motif chemokine 24 precursor

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables CCR3 chemokine receptor binding	IDA IDA: 通过直接分析推断	11425309	GOA
enables chemokine activity	IDA IDA: 通过直接分析推断	10072545	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28381538	GOA
enables receptor ligand activity	IDA IDA: 通过直接分析推断	11425309	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cytoskeleton organization	IDA IDA: 通过直接分析推断	10072545	GOA
involved in eosinophil chemotaxis	IDA IDA: 通过直接分析推断	10072545	GOA
involved in positive regulation of GTPase activity	IDA IDA: 通过直接分析推断	19525930	GOA
involved in positive regulation of actin filament polymerization	IDA IDA: 通过直接分析推断	19525930	GOA
involved in positive regulation of cell migration	IDA IDA: 通过直接分析推断	19525930	GOA
involved in positive regulation of endothelial cell proliferation	IDA IDA: 通过直接分析推断	19525930	GOA
involved in regulation of cell shape	IDA IDA: 通过直接分析推断	10072545	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CCL24 蛋白结构

IL8

0
100
119 a.a.

蛋白主名

其他名称

C-C motif chemokine 24

CK-beta-6

CCL24 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CCL24	O00175	CCL5	Homo sapiens	P13501	SPR	28381538
种属内	CCL24	O00175	CCL5	Homo sapiens	P13501	Filter Binding	28381538
种属内	CCL24	O00175	CXCL11	Homo sapiens	O14625	Filter Binding	28381538

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CCL24 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7161	CCL24/Eotaxin-2 Protein, Human	O00175 (V27-A104)	≥95%
HY-P7766	CCL24/Eotaxin-2 Protein, Human (HEK293, His)	O00175 (V27-C119)	≥95%

关联疾病

疾病名称

别名

Vernal Keratoconjunctivitis

Vkc	Spring Catarrh
Keratoconjunctivitis Vernal	Keratoconjunctivitis, Vernal

Allergic Asthma

Atopic Asthma	Extrinsic Asthma
Extrinsic Asthma With Acute Exacerbation	Extrinsic Asthma With Status Asthmaticus
Asthma Allergic	Atopic Asthma, Susceptibility To
Ige-Mediated Allergic Asthma	Allergen-Induced Asthma
Allergic Asthma Without Stated Status Asthmaticus	Predominantly Allergic Asthma Without Stated Status Asthmaticus
Predominantly Allergic Asthma	Allergic Asthma Nos
Catarrh With Asthma	Allergic Bronchitis Nos
Extrinsic Allergic Asthma	Predominantly Allergic Asthma With Stated Status Asthmaticus

Neurosyphilis

Syphilis Of Central Nervous System	Late Syphilis Of Central Nervous System Nos
Late Syphilis Of The Central Nervous System	Gumma Of Central Nervous System
Neurosyphilis Gumma	Neurosyphilitic Gumma
Syphilis Of Central Nervous System Nos	Syphilitic Gumma Of Central Nervous System
Tertiary Central Nervous System Syphilis

Parenchymatous Neurosyphilis

Mansonelliasis

Mansonellosis	Mansonella Perstans Infections
Mansonella Infestation

Hypereosinophilic Syndrome

Eosinophilia	HES
Eosinophilic Leukocytosis	Hypereosinophilic Syndrome, Idiopathic
Idiopathic Hypereosinophilic Syndrome	Disseminated Eosinophilic Collagen Disease
Eosinophilic Disorder	Disorders With Increased Eosinophil Counts

Allergic Disease

Hypersensitivity	Allergic Hypersensitivity Disease
Allergic Condition	Allergic Reaction
Allergic Disposition

Allergic Rhinitis

Hay Fever	Allergic Rhinitis, Susceptibility To
ALRH	Atopic Rhinitis
Seasonal Allergic Rhinitis	Non-Seasonal Allergic Rhinitis
Perenial Allergic Rhinitis	Pollenosis
Rhinitis Allergic Seasonal	Rhinitis, Allergic, Perennial
Allergic Rhinitis, Cause Unspecified	Pollinosis
Pollen Allergy	Allergy Nos Due To Pollen
Summer Catarrh	Other Seasonal Allergic Rhinitis

Esophagitis

Acute Esophagitis

Papillary Conjunctivitis

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Conjunctivitis

Madras Eye	Adenoviral Conjunctivitis
Acute Adenoviral Follicular Conjunctivitis	Inclusion Conjunctivitis Of The Adult
Swimming-Pool Conjunctivitis	Inflammation Of Conjunctiva
Ophthalmia	Acute Conjunctivitis
Eye Catarrh	Catarrhal Ophthalmia
Koch-Weeks Conjunctivitis

Giant Papillary Conjunctivitis

Gpc	Conjunctivitis Giant Papillary
Conjunctivitis, Giant Papillary	Chronic Giant Papillary Conjunctivitis
Chronic Papillary Conjunctivitis

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Eosinophilic Gastritis

Eosinophilic Enteropathy

Angiostrongyliasis

A. Cantonensis Angiostrongyliasis

Chronic Asthma

Respiratory Allergy

Airway Allergy

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02094	CCL24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P991010	Nebokitug	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	CCL24	VGNC	VGNC:38886
Macaca mulatta	CCL24	VGNC	VGNC:80856
Mus musculus	CCL24	MGD	MGI:1928953
Bos taurus	CCL24	VGNC	VGNC:26950
Felis catus	CCL24	VGNC	VGNC:60544
Rattus norvegicus	CCL24	RGD	RGD:1310245
Macaca fascicularis	CCL24	NCBI	NCBI:102135519
Others	CCL24	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CCL24 - C-C motif chemokine ligand 24 Gene

关于 CCL24

功能概要

CCL24 基因产物(2)

CCL24 蛋白结构

CCL24 蛋白互作信息

重组 CCL24 蛋白

关联疾病

直系同源

热门区域

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CCL24 - C-C motif chemokine ligand 24 Gene

关于 CCL24

功能概要

CCL24 基因产物(2)

CCL24 蛋白结构

CCL24 蛋白互作信息

重组 CCL24 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z