PRDM1 - PR/SET domain 1 Gene

中文名称：PR/SET 域 1

种属: Homo sapiens

同用名: BLIMP1; PRDI-BF1

基因 ID: 639 | 基因类型: protein coding

关于 PRDM1

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:105,992,690-106,109,938 (from NCBI)

This gene has 10 transcripts (splice variants), 211 orthologues, 36 paralogues and is associated with 99 phenotypes. Broad expression in esophagus (RPKM 16.3), endometrium (RPKM 7.2) and 17 other tissues.

功能概要

该基因编码的蛋白质可作为 β-干扰素基因表达的阻遏物。该蛋白与 β-IFN 基因启动子的 PRDI (正调控域 I 元件) 特异性结合。该基因的转录在病毒诱导后增加。已经报道了编码不同亚型的两种选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. [provided by RefSeq, Jul 2008]

PRDM1 基因产物(2)

mRNA	Protein	Name
NM_001198.4	NP_001189.2	PR domain zinc finger protein 1 isoform 1
NM_182907.3	NP_878911.1	PR domain zinc finger protein 1 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	1851123	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	1851123	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	22555612	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: 通过直接分析推断	28473536	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	1851123	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	21421998	GOA
located in nucleus	IDA IDA: 通过直接分析推断	28842558	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRDM1 蛋白结构

SET

zf-H2C2_2

0
200
400
600
825 a.a.

蛋白主名

其他名称

PR domain zinc finger protein 1

B-lymphocyte-induced maturation protein 1

PRDM1 抗体

目录号	产品名	应用	反应物种
HY-P81356	PRDM1/Blimp1 Antibody (YA1101)	IHC-P	Human

关联疾病

疾病名称

别名

Plasmablastic Lymphoma

Pbl	Immunoblastic Large-Cell Lymphoma

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Selective Igg Deficiency Disease

Igg Deficiency	Immunoglobin G Subclass Deficiency
Selective Deficiency Of Igg	Selective Igg Immunodeficiency
Selective Immunoglobulin G Deficiency	Selective Immunoglobulin G Subclass Deficiency

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

B-Cell Non-Hodgkin Lymphoma

B-Cell Nhl

B-Cell Non-Hodgkins Lymphoma

Monoclonal Paraproteinemia

Monoclonal Paraproteinaemia

Plasmacytoma

Solitary Plasmacytoma	Solitary Myeloma
Myeloma - Solitary	Myeloma, Solitary
Plasmacytoma - Category	Solitary Osseous Plasmacytoma
Solitary Plasmacytoma Without Mention Of Remission	Localised Malignant Plasma Cell Tumour Nos
Plasmacytoma Nos

Oral Hairy Leukoplakia

Hairy Leukoplakia	Leukoplakia, Hairy
Hairy Leucoplakia

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Common Variable Immunodeficiency

Cvid	Common Variable Agammaglobulinemia
Common Variable Immune Deficiency	Acquired Hypogammaglobulinemia
Hypogamma-Globulinemia, Acquired	Idiopathic Immunoglobulin Deficiency
Primary Antibody Deficiency	Primary Hypogammaglobulinemia
Acquired Agammaglobulinemia	Sporadic Hypogammaglobulinemia
Common Variable Hypogamma-Globulinemia	Immunoglobulin Deficiency, Late-Onset
Common Variable Hypogammaglobulinemia	Immunodeficiency, Common Variable

Immunodeficiency 60

Bach2-Related Immunodeficiency And Autoimmunity	Brida
Imd60

Adult Lymphoma

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Mature B-Cell Neoplasm

Mature B-Cell Lymphocytic Neoplasm	Neoplasm Of Mature B-Cells
Mature B-Cell Non-Hodgkin Neoplasm With Leukaemic Behaviour

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11059	PRDM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PRDM1	VGNC	VGNC:44944
Felis catus	PRDM1	VGNC	VGNC:69033
Macaca mulatta	PRDM1	VGNC	VGNC:76391
Rattus norvegicus	PRDM1	RGD	RGD:1311765
Bos taurus	PRDM1	VGNC	VGNC:33288
Mus musculus	PRDM1	MGD	MGI:99655
Others	PRDM1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PRDM1 - PR/SET domain 1 Gene

关于 PRDM1

功能概要

PRDM1 基因产物(2)

PRDM1 蛋白结构

PRDM1 抗体

关联疾病

直系同源

热门区域

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PRDM1 - PR/SET domain 1 Gene

关于 PRDM1

功能概要

PRDM1 基因产物(2)

PRDM1 蛋白结构

PRDM1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z