2. Gene
  3. CRLF2 - cytokine receptor like factor 2 Gene

CRLF2 - cytokine receptor like factor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：细胞因子受体样因子 2

种属: Homo sapiens

同用名: CRL2; TSLPR; CRLF2Y

基因 ID: 64109 | 基因类型: protein coding

关于 CRLF2

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,190,490-1,212,649 (from NCBI)

This gene has 4 transcripts (splice variants), 496 orthologues, 23 paralogues and is associated with 66 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码 I 型细胞因子受体家族的成员。编码的蛋白质是胸腺基质淋巴细胞生成素 (TSLP) 的受体。编码的蛋白质和 TSLP 与白细胞介素 7 受体 (IL7R) 一起激活 STAT3、STAT5 和 JAK2 通路，这些通路控制细胞增殖和造血系统发育等过程。该基因与 14 号染色体上的免疫球蛋白重链基因 (IGH) 或同一 X 或 Y 染色体上的 P2Y 嘌呤受体 8 基因 (P2RY8) 重排与 B 祖细胞急性淋巴细胞白血病 (ALL) 和唐氏综合症 ALL 相关。已发现该基因的可变剪接转录物变体。[RefSeq 提供，2014 年 9 月]

This gene encodes a member of the type I cytokine receptor family. The encoded protein is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Rearrangement of this gene with immunoglobulin heavy chain gene (IGH) on chromosome 14, or with P2Y purinoceptor 8 gene (P2RY8) on the same X or Y chromosomes is associated with B-progenitor acute lymphoblastic leukemia (ALL) and Down syndrome ALL. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

CRLF2 基因产物(2)

mRNA Protein Name
NM_001012288.3 NP_001012288.2 cytokine receptor-like factor 2 isoform 2
NM_022148.4 NP_071431.2 cytokine receptor-like factor 2 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables coreceptor activity IDA
IDA: 通过直接分析推断
20974963 GOA
enables cytokine receptor activity IDA
IDA: 通过直接分析推断
11418668 GOA
enables cytokine receptor activity IMP
IMP: 通过突变表型推断
17242164 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
11418668 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
11418668 GOA
involved in positive regulation of interleukin-5 production IMP
IMP: 通过突变表型推断
17242164 GOA
involved in positive regulation of mast cell activation IMP
IMP: 通过突变表型推断
17242164 GOA
involved in positive regulation of receptor signaling pathway via STAT IDA
IDA: 通过直接分析推断
11418668 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRLF2 蛋白结构

(167 - 213)

  • 0
  • 100
  • 200
  • 233 a.a.
蛋白主名 其他名称

cytokine receptor-like factor 2

IL-XR

重组 CRLF2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70794 TSLP R Protein, Human (HEK293, Fc) Q9HC73 (G25-K231) ≥95%
HY-P71389 TSLP R Protein, Human (HEK293, His) Q9HC73 (G25-K231) ≥95%

关联疾病

疾病名称 别名
Lymphoblastic Leukemia, Acute, With Lymphomatous Features

LALL

Lymphomatous All

Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia With Lymphomatous Features
Down Syndrome

Trisomy 21

Complete Trisomy 21 Syndrome

Down'S Syndrome

Trisomy 21 Syndrome

Down'S Syndrome - Trisomy 21

Downs Syndrome

G Trisomy

47,Xx,+21

47,Xy,+21

Trisomy G

Down Syndrome, Susceptibility To

Chromosome 21 Trisomy

Trisomy 21 Nos

Abnormal Autosomes 21
B-Lymphoblastic Leukemia/Lymphoma With Bcr-Abl1

B-All With Bcr-Abl1

B-Lymphoblastic Leukemia/Lymphoma With T(9

22)(Q34.1

Q11.2)

Bcr-Abl1

B Lymphoblastic Leukemia/Lymphoma With T(9

22)(Q34.1

Q11.2)

Bcr-Abl1
B-Lymphoblastic Leukemia/Lymphoma With Iamp21

B-All With Iamp21

Intrachromosomal Amplification Of Chromosome 21
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Intellectual Developmental Disorder, Autosomal Dominant 33

MRD33

Autosomal Dominant Non-Syndromic Intellectual Disability 33

Mental Retardation, Autosomal Dominant 33

Autosomal Dominant Intellectual Developmental Disorder 33

Autosomal Dominant Mental Retardation 33

Mental Retardation, Autosomal Dominant, Type 33
Adult Acute Lymphocytic Leukemia

Adult Acute Lymphoid Leukemia

Adult All
B-Lymphoblastic Leukemia/Lymphoma

B Lymphoblastic Leukemia/Lymphoma

B-All

Precursor B Lymphoblastic Lymphoma/Leukemia

C-All

Lymphoblastic Lymphoma, Nos

Common Precursor B All

Lymphoblastic B-Cell Lymphoma

Pro-B All

B-Precursor Lymphoma

Lbl - [Lymphoblastic Lymphoma]
Chromosomal Duplication Syndrome
Testicular Leukemia
Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis

EOE1

Esophagitis, Eosinophilic

Ee
Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact
Allergic Contact Dermatitis

Dermatitis, Allergic Contact

Contact Dermatitis, Allergic

Dermatitis Allergic Contact

Allergic Contact Eczema

Acd - [Allergic Contact Dermatitis]

Allergic Contact Dermatitis, Unspecified Cause

Allergic Dermatitis

Allergic Eczema

Allergy Dermatitis

Allergy Eczema

Allergic Contact Eczema Due To Clothing Or Footwear

Perfume Allergic Contact Dermatitis

Allergic Contact Dermatitis Due To Cosmetics

Allergic Contact Eczema Due To Cosmetics Or Fragrances

Allergic Contact Eczema Due To Dental Materials

Allergic Contact Eczema Due To Food Flavours Or Additives

Allergic Contact Eczema Due To Hairdressing Products

Allergic Contact Eczema Due To Metals Or Metal Salts

Allergic Contact Eczema Due To Proteins

Allergic Contact Eczema Due To Plastics Or Resin Systems

Allergic Contact Eczema Due To Preservatives Or Biocides

Allergic Contact Eczema Due To Rubber Chemicals

Rubber Dermatitis

Allergic Contact Eczema Due To Systemic Medicaments

Allergic Contact Eczema Due To Topical Medicaments

Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Dermatitis, Atopic

Atopic Dermatitis

Atopic Eczema

Dermatitis, Atopic, Susceptibility To, 1

Atod

Eczema, Atopic

Dermatitis, Atopic 1

Allergic Dermatitis

Atopic Neurodermatitis

Besnier'S Prurigo

Dermatitis, Atopic, 1

Dermatitis Atopic

Eczema

Besnier Prurigo
Leukemia, Acute Lymphoblastic

Acute Lymphoblastic Leukemia

ALL

Acute Lymphocytic Leukemia

Leukemia, Acute Lymphocytic, Susceptibility To, 1

Acute Lymphoblastic Leukaemia

Precursor Lymphoblastic Lymphoma/Leukemia

Precursor Lymphoid Neoplasm

Leukemia, Acute Lymphoblastic, Susceptibility To

B-Cell Acute Lymphoblastic Leukemia

Leukemia, Acute Lymphocytic 1

Acute Lymphocytic Leukaemia

Acute Lymphoblastic Leukemia/Lymphoma

All1

Childhood Acute Lymphoblastic Leukemia

Leukemia Acute Lymphoblastic 1

Leukemia Acute Lymphoblastic B-Hyperdiploid

Leukemia Acute Lymphocytic

Leukemia Acute Lymphocytic 1

Leukemia B-Cell Acute Lymphoblastic

Leukemia T-Cell Acute Lymphoblastic

Leukemia, Acute Lymphoblastic, 3

ALL3

Lymphoblastic Leukemia Acute

Leukemia, Acute, Lymphoblastic

Precursor Cell Lymphoblastic Leukemia Lymphoma

Leukemia, Lymphocytic, Acute, L1

Leukemia, Acute Lymphoblastic, Susceptibility To, 3
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-151902 SJ988497 98.05% 否
HY-RS03187 CRLF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990774 Verekitug Inhibitor 97.00% 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CRLF2 VGNC VGNC:39621
Rattus norvegicus CRLF2 RGD RGD:621078
Mus musculus CRLF2 MGD MGI:1889506
Macaca fascicularis CRLF2 NCBI NCBI:123571109
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