2. Gene
  3. TMBIM1 - transmembrane BAX inhibitor motif containing 1 Gene

TMBIM1 - transmembrane BAX inhibitor motif containing 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：含跨膜 BAX 抑制剂基序 1

种属: Homo sapiens

同用名: LFG3; RECS1; MST100; PP1201; MSTP100

基因 ID: 64114 | 基因类型: protein coding

关于 TMBIM1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,274,197-218,292,503 (from NCBI)

This gene has 23 transcripts (splice variants), 254 orthologues and 5 paralogues. Ubiquitous expression in esophagus (RPKM 69.4), fat (RPKM 68.5) and 25 other tissues.

功能概要

启用死亡受体结合活性。参与 Fas 信号通路的负调控；通过死亡域受体负调控外源性凋亡信号通路；和蛋白质定位到质膜的负调节。位于高尔基体；内体膜；和溶酶体膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables death receptor binding activity. Involved in negative regulation of Fas signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of protein localization to plasma membrane. Located in Golgi apparatus; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMBIM1 基因产物(10)

mRNA Protein Name
NM_001321427.2 NP_001308356.1 protein lifeguard 3 isoform 1
NM_001321428.2 NP_001308357.1 protein lifeguard 3 isoform 1
NM_001321429.2 NP_001308358.1 protein lifeguard 3 isoform 1
NM_001321430.2 NP_001308359.1 protein lifeguard 3 isoform 1
NM_001321432.2 NP_001308361.1 protein lifeguard 3 isoform 1
NM_001321433.2 NP_001308362.1 protein lifeguard 3 isoform 1
NM_001321435.2 NP_001308364.1 protein lifeguard 3 isoform 1
NM_001321436.2 NP_001308365.1 protein lifeguard 3 isoform 1
NM_001321438.2 NP_001308367.1 protein lifeguard 3 isoform 2
NM_022152.6 NP_071435.2 protein lifeguard 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables death receptor binding IDA
IDA: 通过直接分析推断
21107705 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of Fas signaling pathway IMP
IMP: 通过突变表型推断
21107705 GOA
involved in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IMP
IMP: 通过突变表型推断
21107705 GOA
involved in negative regulation of protein localization to plasma membrane IMP
IMP: 通过突变表型推断
21107705 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
21107705 GOA
located in endosome membrane IDA
IDA: 通过直接分析推断
16607040 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
16607040 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TMBIM1 蛋白结构

Bax1-I

Bax1-I: Inhibitor of apoptosis-promoting Bax1 (97 - 307)

  • 0
  • 100
  • 200
  • 311 a.a.
蛋白主名 其他名称

protein lifeguard 3

transmembrane BAX inhibitor motif-containing protein 1

TMBIM1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TMBIM1 Q969X1 TMEM242 Homo sapiens Q9NWH2
Validated Y2H
32296183
Intra TMBIM1 Q969X1 TMEM242 Homo sapiens Q9NWH2
Y2H Array
32296183
Intra TMBIM1 Q969X1 TMEM242 Homo sapiens Q9NWH2
Y2H Prey Pooling
32296183
Intra TMBIM1 Q969X1 RIC3 Homo sapiens Q7Z5B4-5
Y2H Prey Pooling
32296183
Intra TMBIM1 Q969X1 RIC3 Homo sapiens Q7Z5B4-5
Y2H Array
32296183
Intra TMBIM1 Q969X1 B3GALNT2 Homo sapiens Q8NCR0
Y2H Prey Pooling
32296183
Intra TMBIM1 Q969X1 PROK2 Homo sapiens Q9HC23
Y2H Prey Pooling
32296183
Intra TMBIM1 Q969X1 PROK2 Homo sapiens Q9HC23
Validated Y2H
32296183
Intra TMBIM1 Q969X1 PROK2 Homo sapiens Q9HC23
Y2H Array
32296183
Intra TMBIM1 Q969X1 GGT6 Homo sapiens Q6P531
Y2H Prey Pooling
32296183
Intra TMBIM1 Q969X1 GGT6 Homo sapiens Q6P531
Y2H Array
32296183
Intra TMBIM1 Q969X1 CD33 Homo sapiens P20138
Y2H Prey Pooling
32296183
Intra TMBIM1 Q969X1 CD33 Homo sapiens P20138
Y2H Array
32296183
Intra TMBIM1 Q969X1 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra TMBIM1 Q969X1 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra TMBIM1 Q969X1 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra TMBIM1 Q969X1 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14618 TMBIM1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TMBIM1 VGNC VGNC:66232
Rattus norvegicus TMBIM1 RGD RGD:1359409
Canis familiaris TMBIM1 VGNC VGNC:49789
Macaca mulatta TMBIM1 VGNC VGNC:79392
Mus musculus TMBIM1 MGD MGI:1916910
Bos taurus TMBIM1 VGNC VGNC:35915
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