2. Gene
  3. VSIR - V-set immunoregulatory receptor Gene

VSIR - V-set immunoregulatory receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：V 集免疫调节受体

种属: Homo sapiens

同用名: B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha

基因 ID: 64115 | 基因类型: protein coding

关于 VSIR

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:71,747,556-71,773,520 (from NCBI)

This gene has 3 transcripts (splice variants), 482 orthologues and 14 paralogues. Broad expression in spleen (RPKM 39.2), bone marrow (RPKM 38.8) and 23 other tissues.

功能概要

启用内肽酶激活剂活性；酶结合活性；和相同的蛋白质结合活性。参与多个过程，包括细胞因子产生的负调节；大分子代谢过程的正向调控；和 T 细胞活化的调节。位于质膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables endopeptidase activator activity; Enzyme binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of macromolecule metabolic process; and regulation of T cell activation. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

VSIR 基因产物(1)

mRNA Protein Name
NM_022153.2 NP_071436.1 V-type immunoglobulin domain-containing suppressor of T-cell activation precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activator activity IDA
IDA: 通过直接分析推断
20666777 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
20666777 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
26228159 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
24691993 GOA
involved in negative regulation of CD8-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
24691993 GOA
involved in negative regulation of interleukin-10 production IDA
IDA: 通过直接分析推断
24691993 GOA
involved in negative regulation of interleukin-17 production IDA
IDA: 通过直接分析推断
24691993 GOA
involved in negative regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
24691993 GOA
involved in negative regulation of type II interferon production IDA
IDA: 通过直接分析推断
24691993 GOA
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
20666777 GOA
involved in positive regulation of collagen catabolic process IDA
IDA: 通过直接分析推断
20666777 GOA
involved in positive regulation of endopeptidase activity IDA
IDA: 通过直接分析推断
20666777 GOA
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
20666777 GOA
involved in positive regulation of regulatory T cell differentiation IMP
IMP: 通过突变表型推断
24691993 GOA
involved in zymogen activation IDA
IDA: 通过直接分析推断
20666777 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
20666777 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VSIR 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (43 - 150)

  • 0
  • 100
  • 200
  • 311 a.a.
蛋白主名 其他名称

V-type immunoglobulin domain-containing suppressor of T-cell activation

Death Domain1alpha

VSIR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
VSIR Q9H7M9 TMEM14C Homo sapiens Q9P0S9
Validated Y2H
32296183
种属内
VSIR Q9H7M9 VSIR Homo sapiens Q9H7M9
Pull Down
26228159
种属内
VSIR Q9H7M9 VSIR Homo sapiens Q9H7M9
Anti Tag CoIP
26228159
种属内
VSIR Q9H7M9 VSIR Homo sapiens Q9H7M9
Crosslink
26228159
种属内
VSIR Q9H7M9 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
种属内
VSIR Q9H7M9 TMEM100 Homo sapiens Q9NV29
Validated Y2H
32296183
种属内
VSIR Q9H7M9 DOLK Homo sapiens Q9UPQ8
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 VSIR 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70983 VISTA/B7-H5 Protein, Human (HEK293, His) AAH20568.1 (F33-A194) ≥95%
HY-P77879 VISTA/B7-H5 Protein, Human (HEK293, Fc) Q9H7M9 (F33-A194) ≥95%
HY-P78936 VISTA/B7-H5 Protein, Human (Biotinylated, HEK293, His-Avi) Q9H7M9 (F33-A194) ≥95%

VSIR 抗体

目录号 产品名 应用 反应物种
HY-P81531 VISTA Antibody (YA1276) IHC-P Human

关联疾病

疾病名称 别名
Hard Palate Cancer

Malignant Neoplasm Of Hard Palate

Malignant Tumor Of Hard Palate

Malignant Tumour Of Hard Palate
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15711 VSIR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta VSIR VGNC VGNC:79834
Canis familiaris VSIR VGNC VGNC:51998
Bos taurus VSIR VGNC VGNC:50150
Rattus norvegicus VSIR RGD RGD:1590938
Felis catus VSIR VGNC VGNC:66980
Mus musculus VSIR MGD MGI:1921298
Others VSIR NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z