PDLIM2 - PDZ and LIM domain 2 Gene

中文名称：PDZ 和 LIM 域 2

种属: Homo sapiens

同用名: SLIM; MYSTIQUE

基因 ID: 64236 | 基因类型: protein coding

关于 PDLIM2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,578,741-22,598,026 (from NCBI)

This gene has 20 transcripts (splice variants), 201 orthologues and 7 paralogues. Broad expression in spleen (RPKM 22.4), lung (RPKM 9.5) and 21 other tissues.

功能概要

该基因编码 PDZ-LIM 结构域蛋白的 ALP 亚家族成员。编码的蛋白质通过 PDZ 结构域与肌动蛋白细胞骨架的相互作用抑制贴壁依赖性生长并促进细胞迁移和粘附。编码的蛋白质也是一种推定的肿瘤抑制蛋白，该基因的表达降低与多种恶性肿瘤有关，包括乳腺癌和成人 T 细胞白血病。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 10 月]

This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin Cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast Cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

PDLIM2 基因产物(4)

mRNA	Protein	Name
NM_001368120.1	NP_001355049.1	PDZ and LIM domain protein 2 isoform 4
NM_021630.6	NP_067643.3	PDZ and LIM domain protein 2 isoform 2
NM_176871.5	NP_789847.1	PDZ and LIM domain protein 2 isoform 1
NM_198042.4	NP_932159.1	PDZ and LIM domain protein 2 isoform 3

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	21044950	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDLIM2 蛋白结构

PDZ

LIM

0
100
200
300
352 a.a.

蛋白主名

其他名称

PDZ and LIM domain protein 2

PDLIM2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	PDLIM2	Q96JY6	ACD	Homo sapiens	Q96AP0	Pull Down	21044950

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10280	PDLIM2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	PDLIM2	VGNC	VGNC:44384
Macaca mulatta	PDLIM2	VGNC	VGNC:82203
Felis catus	PDLIM2	VGNC	VGNC:78547
Bos taurus	PDLIM2	VGNC	VGNC:32708
Mus musculus	PDLIM2	MGD	MGI:2384850
Rattus norvegicus	PDLIM2	RGD	RGD:1359203

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