2. Gene
  3. Htr6 - 5-hydroxytryptamine receptor 6 Gene

Htr6 - 5-hydroxytryptamine receptor 6 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：5-羟色胺受体 6

种属: Rattus norvegicus

基因 ID: 64354 | 基因类型: protein coding

关于 Htr6

Primary_assembly 5: 151,296,662-151,311,912 reverse strand.mRatBN7.2:CM026978.1

This gene has 1 transcript (splice variant), 55 orthologues, 35 paralogues and is associated with 5 phenotypes. Restricted expression toward (RPKM 8.2).

功能概要

该基因编码的蛋白可启动 G 蛋白偶联血清素受体活性。参与多个过程，包括G蛋白偶联受体信号通路，偶联环核苷酸第二信使；长期突触增强；和调节胺运输。位于树突和质膜中。该基因的人类直系同源物与阿尔茨海默病有关。与人类 HTR6（5-羟色胺受体 6）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled serotonin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; long-term synaptic potentiation; and regulation of amine transport. Located in dendrite and plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human HTR6 (5-hydroxytryptamine receptor 6). [provided by Alliance of Genome Resources, Apr 2022]

Htr6 基因产物(1)

mRNA Protein Name
NM_024365.2 NP_077341.2 5-hydroxytryptamine receptor 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled serotonin receptor activity IDA
IDA: 通过直接分析推断
7680751 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
24614691 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IMP
IMP: 通过突变表型推断
7680751 RGD
involved in learning IDA
IDA: 通过直接分析推断
17192775 RGD
involved in long-term synaptic potentiation IMP
IMP: 通过突变表型推断
19660530 RGD
involved in negative regulation of acetylcholine secretion, neurotransmission IMP
IMP: 通过突变表型推断
16987217 RGD
involved in negative regulation of gamma-aminobutyric acid secretion IMP
IMP: 通过突变表型推断
16987217 RGD
involved in negative regulation of glutamate secretion IMP
IMP: 通过突变表型推断
16987217 RGD
involved in positive regulation of dopamine secretion IMP
IMP: 通过突变表型推断
16987217 RGD
involved in positive regulation of gamma-aminobutyric acid secretion IMP
IMP: 通过突变表型推断
19660530 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
17122082 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
10427606 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendrite IDA
IDA: 通过直接分析推断
10432491 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Htr6 蛋白结构

7tmA_5-HT6

7tmA_5-HT6: cd15054 (28 - 53)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (28 - 330)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (60 - 86)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (98 - 128)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (140 - 163)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (184 - 213)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (260 - 290)

7tmA_5-HT6

7tmA_5-HT6: cd15054 (298 - 323)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 438 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 6

5-HT-6

5-HT6

5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled

ST-B17

serotonin receptor 6

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06480 HTR6 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06481 Htr6 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06482 Htr6 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Htr6 NCBI NCBI:3362
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