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  2. HTR6 - 5-hydroxytryptamine receptor 6 Gene

HTR6 - 5-hydroxytryptamine receptor 6 Gene

中文名称:5-羟色胺受体 6

种属: Homo sapiens

同用名: 5-HT6; 5-HT6R

基因 ID: 3362 | 基因类型: protein coding

关于 HTR6

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,664,875-19,680,966 (from NCBI)

This gene has 1 transcript (splice variant), 114 orthologues and 8 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白质属于七次跨膜 G 蛋白偶联受体蛋白家族。编码的蛋白质与 Gs α 亚基结合并刺激腺苷酸环化酶激活环 AMP 依赖性信号通路。这种受体被认为可以调节大脑中的胆碱能神经元传递。几种抗抑郁药和抗精神病药对该受体具有高亲和力。[RefSeq 提供,2013 年 8 月]

This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates Adenylate Cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]

HTR6 基因产物(1)

mRNA Protein Name
NM_000871.3 NP_000862.1 5-hydroxytryptamine receptor 6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled serotonin receptor activity IDA
IDA: 通过直接分析推断
35714614 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17189269 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating serotonin receptor signaling pathway IDA
IDA: 通过直接分析推断
35714614 GOA
involved in positive regulation of TOR signaling IDA
IDA: 通过直接分析推断
23027611 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in plasma membrane IDA
IDA: 通过直接分析推断
37327704 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HTR6 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 320)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 440 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 6

5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled

serotonin receptor 6

HTR6 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HTR6 P50406 FYN Homo sapiens P06241
Y2H
17189269
种属内
HTR6 P50406 FYN Homo sapiens P06241
Anti Tag CoIP
17189269
种属内
HTR6 P50406 FYN Homo sapiens P06241
Anti Bait CoIP
17189269
种属内
HTR6 P50406 FYN Homo sapiens P06241
Pull Down
17189269
种属内
HTR6 P50406 MAP1B Homo sapiens P46821
Pull Down
24614691
种属内
HTR6 P50406 MAP1B Homo sapiens P46821
Y2H
24614691
种属内
HTR6 P50406 MAP1B Homo sapiens P46821
Anti Tag CoIP
24614691
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mood Disorder

Mood Disorders

Episodic Mood Disorder

Meckel Syndrome, Type 1

Meckel Syndrome

Meckel-Gruber Syndrome

Dysencephalia Splanchnocystica

Meckel Syndrome 1

MKS1

Mks

Gruber Syndrome

Meckel-Gruber Syndrome, Type 1

Mes

Dysencephalia Splachnocystica

Meckel Gruber Syndrome

Meckel Syndrome Type 1

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus HTR6 VGNC VGNC:80238
Macaca mulatta HTR6 VGNC VGNC:106385
Canis familiaris HTR6 VGNC VGNC:41833
Bos taurus HTR6 VGNC VGNC:30002
Mus musculus HTR6 MGD MGI:1196627
Rattus norvegicus HTR6 RGD RGD:62044