2. Gene
  3. Crhr2 - corticotropin releasing hormone receptor 2 Gene

Crhr2 - corticotropin releasing hormone receptor 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：促肾上腺皮质激素释放激素受体 2

种属: Rattus norvegicus

同用名: Crf2r; CRF-R 2; CRH-R 2

基因 ID: 64680 | 基因类型: protein coding

关于 Crhr2

Primary_assembly 4: 84,224,002-84,265,904 reverse strand.mRatBN7.2:CM026977.1

This gene has 4 transcripts (splice variants), 203 orthologues, 42 paralogues and is associated with 23 phenotypes. Biased expression in Muscle (RPKM 8.2), Heart (RPKM 5.4) and 5 other tissues.

功能概要

该基因编码的蛋白可启动促肾上腺皮质激素释放激素受体活性和肽激素结合活性。涉及多个过程，包括分泌的负调节；基因表达的调节；和细胞内信号转导的调节。位于多个细胞成分中，包括轴突；胞体纤维；和周核体。用于研究结肠炎；缺血;和肌肉萎缩。结肠炎的生物标志物；功能性结肠疾病；肠易激综合症;和精神抑郁症。该基因的人类直系同源物与哮喘有关。与人类 CRHR2（促肾上腺皮质激素释放激素受体 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables corticotropin-releasing hormone receptor activity and peptide hormone binding activity. Involved in several processes, including negative regulation of secretion; regulation of gene expression; and regulation of intracellular signal transduction. Located in several cellular components, including axon; cell body fiber; and perikaryon. Used to study colitis; ischemia; and muscular atrophy. Biomarker of colitis; functional colonic disease; irritable bowel syndrome; and mental depression. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Crhr2 基因产物(1)

mRNA Protein Name
NM_022714.2 NP_073205.2 corticotropin-releasing factor receptor 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables corticotropin-releasing hormone receptor activity IDA
IDA: 通过直接分析推断
12942143 RGD
enables peptide hormone binding IPI
IPI: 通过物理相互作用推断
19334530 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament organization IMP
IMP: 通过突变表型推断
17194738 RGD
involved in catecholamine biosynthetic process IMP
IMP: 通过突变表型推断
17194738 RGD
involved in cellular response to glucocorticoid stimulus IEP
IEP: 通过表达模式推断
21106875 RGD
involved in cerebellum development IEP
IEP: 通过表达模式推断
16820012 RGD
involved in epithelial cell differentiation IMP
IMP: 通过突变表型推断
20551459 RGD
involved in gastric motility IMP
IMP: 通过突变表型推断
16012930 RGD
involved in hypothalamus development IEP
IEP: 通过表达模式推断
20002962 RGD
involved in long-term synaptic potentiation IMP
IMP: 通过突变表型推断
17004937 RGD
involved in negative regulation of calcium ion import IMP
IMP: 通过突变表型推断
19439178 RGD
involved in negative regulation of defecation IMP
IMP: 通过突变表型推断
21277852 RGD
involved in negative regulation of epinephrine secretion IMP
IMP: 通过突变表型推断
17194738 RGD
involved in negative regulation of feeding behavior IDA
IDA: 通过直接分析推断
17050037 RGD
involved in negative regulation of follicle-stimulating hormone secretion IMP
IMP: 通过突变表型推断
19193717 RGD
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
19193717 RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
17360501 RGD
involved in negative regulation of luteinizing hormone secretion IMP
IMP: 通过突变表型推断
19193717 RGD
involved in negative regulation of norepinephrine secretion IMP
IMP: 通过突变表型推断
17194738 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
19439178 RGD
involved in positive regulation of DNA biosynthetic process IMP
IMP: 通过突变表型推断
16005543 RGD
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
19211730 RGD
involved in positive regulation of blood pressure IMP
IMP: 通过突变表型推断
20060787 RGD
involved in positive regulation of cAMP/PKA signal transduction IDA
IDA: 通过直接分析推断
20682782 RGD
involved in positive regulation of cAMP/PKA signal transduction IMP
IMP: 通过突变表型推断
16005543 RGD
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
19193717 RGD
involved in positive regulation of heart rate IMP
IMP: 通过突变表型推断
20060787 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
19211730 RGD
involved in positive regulation of serotonin secretion IMP
IMP: 通过突变表型推断
20655906 RGD
involved in positive regulation of stress-activated MAPK cascade IMP
IMP: 通过突变表型推断
19211730 RGD
involved in regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
21277852 RGD
involved in skeletal muscle tissue growth IDA
IDA: 通过直接分析推断
21235761 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
16820012 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
21481539 RGD
located in cell body fiber IDA
IDA: 通过直接分析推断
21277852 RGD
located in dendrite IDA
IDA: 通过直接分析推断
16820012 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
21277852 RGD
located in perikaryon IDA
IDA: 通过直接分析推断
21453754 RGD
located in varicosity IDA
IDA: 通过直接分析推断
21481539 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Crhr2 蛋白结构

HormR

HormR: smart00008 (55 - 126)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (132 - 395)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (134 - 159)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (168 - 190)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (204 - 231)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (243 - 263)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (280 - 309)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (323 - 350)

7tmB1_CRF-R2

7tmB1_CRF-R2: cd15446 (357 - 382)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
蛋白主名 其他名称

corticotropin-releasing factor receptor 2

CRF-R-2

CRF-R2

CRF2

CRFR-2

CRH-R-2

CRH-R2

corticotrophin releasing hormone receptor 2

corticotropin-releasing factor receptor subtype 2

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P3684A [DPro5] Corticotropin Releasing Factor, human, rat TFA Agonist 99.71% 否
HY-RS03171 CRHR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03172 Crhr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03173 Crhr2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Crhr2 NCBI NCBI:1395
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