[DPro5] Corticotropin Releasing Factor, human, rat TFA 

[DPro5] Corticotropin Releasing Factor, human, rat TFA is a selective corticotropin releasing factor/hormone R2 (CRH-R2)agonist. [DPro5] Corticotropin Releasing Factor, human, rat TFA fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat^[1].

[DPro5] Corticotropin Releasing Factor, human, rat TFA（1 nM；1 小时）可降低海马群体峰值的幅度并防止长时程增强 (LTP) 的发生^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

[DPro5] Corticotropin Releasing Factor, human, rat TFA（0.01-1 μg；静脉注射；单剂量）不会诱导典型的焦虑作用，但会对 Sprague-Dowley 大鼠产生非特异性行为抑制^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4757.45 (free base)

C₂₀₈H₃₄₄N₆₀O₆₃S₂.xC₂HF₃O₂

固体

White to off-white

Ser-Glu-Glu-Pro-{d-Pro}-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Met-Glu-Ile-Ile-NH2

SEEP-{d-Pro}-ISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEII-NH2

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Shabanov PD, et al. [Anxiogenic and mnestic effects of corticoliberin and its analogs introduced into the brain ventriculi of rats]. Eksp Klin Farmakol. 2006 Nov-Dec;69(6):3-8. Russian.  [Content Brief]

  [2]. Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7.  [Content Brief]