2. Gene
  3. P2ry12 - purinergic receptor P2Y12 Gene

P2ry12 - purinergic receptor P2Y12 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2Y12

种属: Rattus norvegicus

同用名: P2y12

基因 ID: 64803 | 基因类型: protein coding

关于 P2ry12

Primary_assembly 2: 143,481,430-143,523,361 reverse strand.mRatBN7.2:CM026975.1

This gene has 3 transcripts (splice variants), 182 orthologues, 6 paralogues and is associated with 22 phenotypes. Biased expression in Brain (RPKM 42.5), Adrenal (RPKM 41.2) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白偶联的 ADP 受体活性。参与多个过程，包括G蛋白偶联受体信号通路；无机阳离子跨膜转运；和细胞内信号转导。位于基底质膜；小窝;和质膜的外侧。与线粒体共定位。用于研究腹主动脉瘤和血栓形成。与哮喘有关的该基因的人类直系同源物；脑血管疾病;外周动脉疾病；血小板型出血性疾病 8；和 2 型糖尿病。与人 P2RY12（嘌呤能受体 P2Y12）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled ADP receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; inorganic cation transmembrane transport; and intracellular signal transduction. Located in basal plasma membrane; caveola; and external side of plasma membrane. Colocalizes with mitochondrion. Used to study abdominal aortic aneurysm and thrombosis. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12). [provided by Alliance of Genome Resources, Apr 2022]

P2ry12 基因产物(1)

mRNA Protein Name
NM_022800.1 NP_073637.1 P2Y purinoceptor 12
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled ADP receptor activity IDA
IDA: 通过直接分析推断
11196645 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled adenosine receptor signaling pathway IMP
IMP: 通过突变表型推断
12814667 RGD
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
11196645 RGD
involved in calcium ion transmembrane transport IDA
IDA: 通过直接分析推断
12080041 RGD
involved in calcium-mediated signaling IMP
IMP: 通过突变表型推断
17299767 RGD
involved in cell projection organization IMP
IMP: 通过突变表型推断
20091784 RGD
involved in cellular response to ATP IMP
IMP: 通过突变表型推断
20091784 RGD
involved in cerebral cortex radial glia-guided migration IMP
IMP: 通过突变表型推断
17299767 RGD
involved in glial cell migration IMP
IMP: 通过突变表型推断
20681951 RGD
involved in lamellipodium assembly IMP
IMP: 通过突变表型推断
20091784 RGD
involved in negative regulation of cell differentiation IMP
IMP: 通过突变表型推断
15056287 RGD
involved in negative regulation of norepinephrine secretion IMP
IMP: 通过突变表型推断
19447154 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
18183622 RGD
involved in positive regulation of cell adhesion mediated by integrin IGI
IGI: 通过遗传相互作用推断
20091784 RGD
involved in positive regulation of chemotaxis IMP
IMP: 通过突变表型推断
18183622 RGD
involved in positive regulation of integrin activation by cell surface receptor linked signal transduction IDA
IDA: 通过直接分析推断
20091784 RGD
involved in positive regulation of microglial cell migration IMP
IMP: 通过突变表型推断
17299767 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
15056287 RGD
involved in positive regulation of ruffle assembly IMP
IMP: 通过突变表型推断
17299767 RGD
involved in potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
12080041 RGD
involved in regulation of calcium ion transport IMP
IMP: 通过突变表型推断
15579146 RGD
involved in regulation of chemotaxis IMP
IMP: 通过突变表型推断
17299767 RGD
involved in response to axon injury IDA
IDA: 通过直接分析推断
14603465 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basal plasma membrane IDA
IDA: 通过直接分析推断
21879346 RGD
located in caveola IDA
IDA: 通过直接分析推断
21879346 RGD
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
11196645 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2ry12 蛋白结构

7tmA_P2Y12

7tmA_P2Y12: cd15150 (31 - 315)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (31 - 58)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (64 - 89)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (102 - 132)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (144 - 166)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (191 - 220)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (240 - 268)

7tmA_P2Y12

7tmA_P2Y12: cd15150 (281 - 305)

  • 0
  • 100
  • 200
  • 300
  • 343 a.a.
蛋白主名 其他名称

P2Y purinoceptor 12

P2Y12 platelet ADP receptor

purinergic receptor P2Y, G-protein coupled, 12

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09919 P2RY12 Human Pre-designed siRNA Set A / 否
HY-RS09920 P2ry12 Mouse Pre-designed siRNA Set A / 否
HY-RS09921 P2ry12 Rat Pre-designed siRNA Set A / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2ry12 NCBI NCBI:64805
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z