YTHDC2 - YTH domain containing 2 Gene

中文名称：含 YTH 域 2

种属: Homo sapiens

同用名: CAHL; hYTHDC2

关于 YTHDC2

功能概要

该基因编码 DEAH (Asp-Glu-Ala-His) 蛋白质亚家族的成员，是 RNA 解旋酶 DEAD (Asp-Glu-Ala-Asp) 盒家族的一部分。编码的蛋白质与 N6-甲基腺苷结合，N6-甲基腺苷是一种常见的修饰 RNA 核苷酸，富含真核信使 RNA 的终止密码子和 3' UTR。蛋白质与这种修饰核苷酸的结合可以调节 mRNA 的翻译和稳定性。该基因可能与人类患者对胰腺癌的易感性有关，并且该基因的敲低导致人类肝癌细胞系的增殖减少。[RefSeq 提供，2016 年 9 月]

This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic Cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver Cancer cell line. [provided by RefSeq, Sep 2016]