1. Gene
  2. USP46 - ubiquitin specific peptidase 46 Gene

USP46 - ubiquitin specific peptidase 46 Gene

中文名称:泛素特异性肽酶 46

种属: Homo sapiens

基因 ID: 64854 | 基因类型: protein coding

关于 USP46

Cytogenetic location: 4q12 Genomic coordinates (GRCh38): 4:52,590,960-52,659,301 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 11.8), heart (RPKM 7.4) and 23 other tissues.

功能概要

泛素对细胞蛋白质的修饰是一种重要的调节机制,由多种泛素结合酶和去泛素化酶的协调作用控制。 USP46 属于一大类半胱氨酸蛋白酶,可作为去泛素化酶发挥作用 (Quesada 等人,2004 年 [PubMed 14715245]) 。[OMIM 提供,2009 年 6 月]

Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating Enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating Enzymes (Quesada et al., 2004 [PubMed 14715245]).[supplied by OMIM, Jun 2009]

USP46 基因产物(4)

mRNA Protein Name
NM_001134223.2 NP_001127695.1 ubiquitin carboxyl-terminal hydrolase 46 isoform 2
NM_001286767.2 NP_001273696.1 ubiquitin carboxyl-terminal hydrolase 46 isoform 3
NM_001286768.2 NP_001273697.1 ubiquitin carboxyl-terminal hydrolase 46 isoform 4
NM_022832.4 NP_073743.2 ubiquitin carboxyl-terminal hydrolase 46 isoform 1

USP46 蛋白结构

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (34 - 362)

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  • 366 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase 46

deubiquitinating enzyme 46

直系同源

种属 基因名 来源 基因 ID
Felis catus USP46 VGNC VGNC:66889
Bos taurus USP46 VGNC VGNC:52847
Macaca mulatta USP46 VGNC VGNC:79229
Rattus norvegicus USP46 RGD RGD:1564808
Mus musculus USP46 MGD MGI:1916977
Canis familiaris USP46 VGNC VGNC:51784
Others USP46 NCBI