PAPOLG - poly(A) polymerase gamma Gene

中文名称：聚 (A) 聚合酶γ

种属: Homo sapiens

关于 PAPOLG

功能概要

该基因编码 poly (A) 聚合酶家族的一个成员，该家族催化 DNA/RNA 链 3' 端的模板独立延伸。这种酶在氨基酸水平上与充分表征的聚 (A) 聚合酶 II (PAPII) 具有 60% 的同一性。这两种酶具有相似的结构和功能域组织。这种酶完全位于细胞核中，并表现出非特异性和 CPSF (裂解和聚腺苷酸化特异性因子) /AAUAAA 依赖性聚腺苷酸化活性。该基因位于 2 号染色体上，而 PAPII 基因位于 14 号染色体上。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This Enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two Enzymes have similar organization of structural and functional domains. This Enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]