2. Gene
  3. SIPA1 - signal-induced proliferation-associated 1 Gene

SIPA1 - signal-induced proliferation-associated 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：信号诱导增殖相关 1

种属: Homo sapiens

同用名: SPA1

基因 ID: 6494 | 基因类型: protein coding

关于 SIPA1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,638,101-65,650,912 (from NCBI)

This gene has 10 transcripts (splice variants), 175 orthologues and 6 paralogues. Broad expression in spleen (RPKM 30.1), lymph node (RPKM 17.9) and 24 other tissues.

功能概要

该基因的产物是有丝分裂原诱导的 GTP 酶激活蛋白 (GAP) 。它对 Ras 相关调节蛋白 Rap1 和 Rap2 表现出特定的 GAP 活性，但对 Ran 或其他小 GTP 酶则没有。当异常或过早表达时，这种蛋白质也可能阻碍有丝分裂原诱导的细胞周期进程。它位于核周区域。迄今为止，已经表征了编码相同亚型的两个可变剪接变体。[RefSeq 提供，2008 年 7 月]

The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or Other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]

SIPA1 基因产物(2)

mRNA Protein Name
NM_006747.4 NP_006738.3 signal-induced proliferation-associated protein 1
NM_153253.30 NP_694985.29 signal-induced proliferation-associated protein 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity EXP
EXP: 通过实验结果推断
16076873 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21988832 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIPA1 蛋白结构

Rap_GAP

Rap_GAP: Rap/ran-GAP (350 - 539)

PDZ

PDZ: PDZ domain (Also known as DHR or GLGF) (688 - 758)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1042 a.a.
蛋白主名 其他名称

signal-induced proliferation-associated protein 1

GTPase-activating protein Spa-1

SIPA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SIPA1 Q96FS4 CDKN1A Homo sapiens P38936
Anti Tag CoIP
21988832
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Juvenile Myelomonocytic Leukemia

Leukemia, Juvenile Myelomonocytic

JMML

Leukemia, Juvenile Myelomonocytic, Somatic

Juvenile Chronic Myelomonocytic Leukemia

Juvenile Chronic Myelogenous Leukemia

Leukemia, Myelomonocytic, Juvenile

Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Myeloproliferative Neoplasm

Myeloproliferative Disorder

Chronic Myeloproliferative Disease

Myeloproliferative Neoplasms

Chronic Myeloproliferative Disorder

Cmpd

Cmpd, U

Chronic Myeloproliferative Disorders

Mpd

Mpn

Myeloproliferative Disorders

Myeloproliferative Disease

Campomelic Dysplasia
Leukemia, Chronic Myeloid

Chronic Myeloid Leukemia

Chronic Myelogenous Leukemia

CML

Chronic Granulocytic Leukemia

Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib

Chronic Myeloid Leukaemia

Chronic Granulocytic Leukaemia

Chronic Myelogenous Leukaemia

Myeloid Leukemia, Chronic

Leukemia, Chronic Myelogenous

Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic

Cml - Chronic Myelogenous Leukemia

Cgl

Chronic Myelocytic Leukemia

Leukemia, Chronic Myeloid, Atypical

ACML

Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative

Myeloid Leukemia Chronic

Leukemia, Myeloid, Chronic

Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative

Cml- [Chronic Myeloid Leukaemia]

Cgl - [Chronic Granulocytic Leukaemia]

Chronic Myelocytic Leukaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12928 SIPA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12929 SIPA1L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12930 SIPA1L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12931 SIPA1L3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SIPA1 MGD MGI:107576
Canis familiaris SIPA1 VGNC VGNC:46179
Macaca mulatta SIPA1 VGNC VGNC:77218
Bos taurus SIPA1 VGNC VGNC:34627
Felis catus SIPA1 VGNC VGNC:65152
Rattus norvegicus SIPA1 RGD RGD:1303184
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