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  2. SLC1A2 - solute carrier family 1 member 2 Gene

SLC1A2 - solute carrier family 1 member 2 Gene

中文名称:溶质载体家族 1 成员 2

种属: Homo sapiens

同用名: GLT1; HBGT; DEE41; EAAT2; GLT-1; EIEE41

基因 ID: 6506 | 基因类型: protein coding

关于 SLC1A2

Cytogenetic location: 11p13 Genomic coordinates (GRCh38): 11:35,251,205-35,420,507 (from NCBI)

This gene has 50 transcripts (splice variants), 287 orthologues, 6 paralogues and is associated with 3 phenotypes. Restricted expression toward brain (RPKM 153.3).

功能概要

该基因编码溶质转运蛋白家族的一个成员。膜结合蛋白是清除中枢神经系统突触细胞外空间的兴奋性神经递质谷氨酸的主要转运蛋白。谷氨酸清除对于适当的突触激活和防止因谷氨酸受体过度激活造成的神经元损伤是必需的。该基因的不当调节被认为与多种神经系统疾病有关。已经鉴定了该基因的可变剪接转录物变体。[RefSeq 提供,2017 年 6 月]

This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Improper regulation of this gene is thought to be associated with several neurological disorders. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2017]

SLC1A2 基因产物(15)

mRNA Protein Name
XM_017018136.1 XP_016873625.1 excitatory amino acid transporter 2 isoform X3
XM_047427443.1 XP_047283399.1 excitatory amino acid transporter 2 isoform X5
NM_004171.4 NP_004162.2 excitatory amino acid transporter 2 isoform 1
XM_017018139.2 XP_016873628.1 excitatory amino acid transporter 2 isoform X7
XM_017018137.2 XP_016873626.1 excitatory amino acid transporter 2 isoform X5
XM_047427437.1 XP_047283393.1 excitatory amino acid transporter 2 isoform X2
XM_017018138.2 XP_016873627.1 excitatory amino acid transporter 2 isoform X5
XM_047427438.1 XP_047283394.1 excitatory amino acid transporter 2 isoform X5
NM_001195728.3 NP_001182657.1 excitatory amino acid transporter 2 isoform 2
XM_047427436.1 XP_047283392.1 excitatory amino acid transporter 2 isoform X1
XM_011520285.2 XP_011518587.1 excitatory amino acid transporter 2 isoform X4
NM_001252652.2 NP_001239581.1 excitatory amino acid transporter 2 isoform 2
XM_047427442.1 XP_047283398.1 excitatory amino acid transporter 2 isoform X5
XM_047427440.1 XP_047283396.1 excitatory amino acid transporter 2 isoform X5
XM_047427441.1 XP_047283397.1 excitatory amino acid transporter 2 isoform X6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-glutamate transmembrane transporter activity IDA
IDA: 通过直接分析推断
7521911 GOA
enables glutamate:sodium symporter activity IDA
IDA: 通过直接分析推断
15265858 GOA
enables high-affinity L-glutamate transmembrane transporter activity IDA
IDA: 通过直接分析推断
26690923 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19527721 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in D-aspartate import across plasma membrane IDA
IDA: 通过直接分析推断
7521911 GOA
involved in L-aspartate import across plasma membrane IDA
IDA: 通过直接分析推断
7521911 GOA
involved in L-glutamate import across plasma membrane IDA
IDA: 通过直接分析推断
7521911 GOA
involved in L-glutamate import across plasma membrane IGI
IGI: 通过遗传相互作用推断
20193040 GOA
involved in L-glutamate transmembrane transport IDA
IDA: 通过直接分析推断
26690923 GOA
involved in protein homotrimerization IDA
IDA: 通过直接分析推断
15265858 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
21399631 GOA
part of membrane protein complex IDA
IDA: 通过直接分析推断
20193040 GOA
located in membrane raft IDA
IDA: 通过直接分析推断
20193040 GOA
located in plasma membrane IMP
IMP: 通过突变表型推断
15265858 GOA
is active in presynaptic membrane IDA
IDA: 通过直接分析推断
21258616 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLC1A2 蛋白结构

SDF

SDF: Sodium:dicarboxylate symporter family (46 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 574 a.a.
蛋白主名 其他名称

excitatory amino acid transporter 2

excitotoxic amino acid transporter 2

glutamate transporter-1

glutamate/aspartate transporter II

human brain glutamate transporter

sodium-dependent glutamate/aspartate transporter 2

solute carrier family 1 (glial high affinity glutamate transporter), member 2

SLC1A2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC1A2 P43004 MAPT Homo sapiens P10636
Anti Bait CoIP
19527721
种属内
SLC1A2 P43004 MAPT Homo sapiens P10636
Pull Down
19527721
种属间: 跨种属相互作用 种属内: 同种属相互作用

SLC1A2 抗体

目录号 产品名 应用 反应物种
HY-P82737 EAAT2 Antibody (YA2482) WB, IP Human, Mouse, Rat

关联疾病

疾病名称 别名
Dicarboxylic Aminoaciduria

Glutamate-Aspartate Transport Defect

Dicarboxylicaminoaciduria

DCBXA

Renal Aminoacidurias

Trichotillomania

TTM

Hair-Pulling Syndrome

Compulsive Hair Plucking

Hair Pulling Disorder

Lateral Sclerosis

Primary Lateral Sclerosis

Adult-Onset Primary Lateral Sclerosis

Adult-Onset Pls

Motor Neuron Disease

Pls

Pls - [Primary Lateral Sclerosis]

Lateral Spinal Sclerosis

Lateral Complete Paralysis

Lateral Incomplete Paralysis

Lateral Paralysis

Cerebral Palsy

Infantile Cerebral Palsy

Mixed Cerebral Palsy

Palsy Cerebral

Palsy, Cerebral

Cerebral Palsy, Mixed

Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder

Brain Edema

Intracranial Swelling

Wet Brain

Cerebral Edema

Hepatic Encephalopathy

Encephalopathy, Hepatic

Portal-Systemic Encephalopathy

Hepatoencephalopathy

He - [Hepatic Encephalopathy]

Hepatic Encephalopathy Nos

Hepatic Encephalopathy, Stage Unspecified

Hepatic Coma

Hepatocerebral Encephalopathy

Hepatocerebral Intoxication

Focal Epilepsy

Partial Epilepsy

Epilepsies, Partial

Localisation-Related Epilepsy

Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident

Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To

Ischemia

Acute Coronary Syndrome

Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2

Neuromyelitis Optica

Devic Disease

Devic Syndrome

Devic'S Disease

Neuromyelitis Optica Spectrum Disorder

Devic'S Syndrome

Devic'S Neuromyelitis Optica

Nmo

Nmo Spectrum Disorder

Neuromyelitis Optica Spectrum Disorders

Devic Neuromyelitis Optica

Optic-Spinal Ms

Opticospinal Ms

Nmosd

Opticospinal Multiple Sclerosis

Devic

Ophthalmoneuromyelitis

Optic Neuromyelitis

Optic Neuroencephalomyelopathy

Nmo - [Neuromyelitis Optica]

Optic Neuritis With Demyelination

Episodic Ataxia, Type 6

Episodic Ataxia Type 6

EA6

Episodic Ataxia 6

Ea-6

Ataxia, Episodic, Type 6

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Childhood Absence Epilepsy

Pyknolepsy

Petit Mal Epilepsy

Absence Seizures

Absence Seizure

Petit Mal Seizure

Absence Epilepsy, Childhood

Pykno-Epilepsy

Epilepsy, Absence

Absence Epilepsy

Pycnolepsy

Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders

Toxic Encephalopathy

Neurotoxicity

Neurotoxicity Syndromes

Neurotoxicity Syndrome

Encephalopathy, Toxic

Migraine, Familial Hemiplegic, 2

FHM2

Mhp2

Migraine, Familial Basilar

Familial Hemiplegic Migraine 2

Familial Hemiplegic Migraine-2

Familiar Basilar Migraine

Migraine, Hemiplegic, Familial, Type 2

Ganglioglioma

Childhood Ganglioglioma

Adult Ganglioglioma

Cns Ganglioglioma

Mixed Cell Tumors Containing Both Neural Ganglionic Cells And Neural Glial Cell Components

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1

Guam Disease

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex Of Guam

Als-Pdc

Lytico-Bodig Disease

Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1, Susceptibility To

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex, Susceptibility To

Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex

Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Of Guam Syndrome

Parkinsonism-Dementia-Als Complex

Pdals

Amyotrophic Lateral Sclerosis, Parkinsonism/Dementia Complex Of Guam

Parkinson-Dementia Complex Of Guam

G-Pdc

Guam Parkinsonism-Dementia Complex

ALS-PDC1

Als/Pdc Of Guam

Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic/Parkinsonism/Dementia Complex 1

Amyotrophic Lateral Sclerosis, Guam Form

Parkinsonian Disorders

Restless Legs Syndrome

Wed

Willis-Ekbom Disease

Restless Leg Syndrome

Ekbom Syndrome

Wittmaack-Ekbom Syndrome

Willis Ekbom Disease

Ekbom'S Syndrome

Rls

Restless Legs

Restless Legs Syndrome, Susceptibility To

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy

Non-Specific Eoee

Undetermined Eoee

Familial Hemiplegic Migraine

Hemiplegic Migraine, Familial

Hemiplegic-Ophthalmoplegic Migraine

Fhm

Hemiplegic Migraine Familial

Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease

Episodic Ataxia

Isaacs Syndrome

Neuromyotonia

Isaacs' Syndrome

Acquired Neuromyotonia

Continuous Muscle Fiber Activity Syndrome

Quantal Squander Syndrome

Isaacs-Mertens Syndrome

Ea Syndrome

Episodic Ataxia Syndrome

Isaac Syndrome

Isaac'S-Merten'S Syndrome

Isaac-Mertens Syndrome

Peripheral Nerve Hyperexcitability

Ea

Ataxia, Episodic

Isaacs Neuromyotonia

Continuous Muscle Fibre Activity

Morphine Dependence
Encephalomalacia
Essential Tremor

Benign Essential Tremor

Familial Tremor

Hereditary Essential Tremor

Essential Hereditary Tremor

Shaky Hand Syndrome

Benign Essential Tremor Syndrome

Tremor Hereditary Essential

Essential Tremor, Susceptibility To

Tremor, Hereditary Essential

Alexander Disease

Alexander'S Disease

ALXDRD

Alexanders Leukodystrophy

Axd

Megalencephaly In Infancy Accompanied By Progressive Spasticity And Dementia

Alx

Demyelinogenic Leukodystrophy

Dysmyelinogenic Leukodystrophy

Fibrinoid Degeneration Of Astrocytes

Leukodystrophy With Rosenthal Fibers

Alexander Disease Type Ii

Axd Type Ii

Alexander Disease Type I

Axd Type I

Alexanders Disease

Alexander'S Leukodystrophy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

Wernicke Encephalopathy

Wernicke'S Encephalopathy

Wernicke'S Disease

Encephalopathy, Wernicke'S

Wernicke-Korsakoff Syndrome

Encephalopathy Due To Vitamin B1 Deficiency

Wernicke Disease

Wernicke Syndrome

Status Epilepticus

Grand Mal Status Epilepticus

Grand Mal Status

Gcse

Generalized Convulsive Status Epilepticus

Se

Epilepsy With Status Epilepticus

Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Congenital Granular Cell Tumor
Psychotic Disorder

Psychotic Disorders

Mental Or Behavioural Disorder

Psychotic

Mental Disorders

Developmental And Epileptic Encephalopathy 41

DEE41

Epileptic Encephalopathy, Early Infantile, 41

Eiee41

Developmental And Epileptic Encephalopathy, 41

Early Infantile Epileptic Encephalopathy 41

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Developmental And Epileptic Encephalopathy 35

DEE35

Epileptic Encephalopathy, Early Infantile, 35

Eiee35

Developmental And Epileptic Encephalopathy, 35

Early Infantile Epileptic Encephalopathy 35

Itpa-Related Encephalopathy

Itpa-Related Lethal Infantile Neurological Disorder With Cataract And Cardiac Involvement

Martsolf-Like Syndrome

Developmental And Epileptic Encephalopathy 24

DEE24

Epileptic Encephalopathy, Early Infantile, 24

Eiee24

Developmental And Epileptic Encephalopathy, 24

Early Infantile Epileptic Encephalopathy 24

Encephalopathy, Epileptic, Early Infantile, Type 24

Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC1A2 MGD MGI:101931
Macaca mulatta SLC1A2 VGNC VGNC:77410
Bos taurus SLC1A2 VGNC VGNC:34712
Felis catus SLC1A2 VGNC VGNC:65230
Rattus norvegicus SLC1A2 RGD RGD:3697
Canis familiaris SLC1A2 VGNC VGNC:46262