BMP3 - bone morphogenetic protein 3 Gene

中文名称：骨形态发生蛋白 3

种属: Homo sapiens

同用名: BMP-3A

关于 BMP3

功能概要

该基因编码 TGF-β (转化生长因子-β) 蛋白质超家族的分泌配体。该家族的配体结合各种 TGF-β 受体，导致调节基因表达的 SMAD 家族转录因子的募集和激活。编码的前原蛋白经过蛋白水解处理，生成二硫键连接的同型二聚体的每个亚基。这种蛋白质通过调节 TGF-β 受体对其他配体的可用性来抑制成骨细胞分化，并负向调节骨密度。[RefSeq 提供，2016 年 7 月]

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta Receptor availability to other ligands. [provided by RefSeq, Jul 2016]