2. Gene
  3. WNK2 - WNK lysine deficient protein kinase 2 Gene

WNK2 - WNK lysine deficient protein kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：WNK 赖氨酸缺陷型蛋白激酶 2

种属: Homo sapiens

同用名: PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13

基因 ID: 65268 | 基因类型: protein coding

关于 WNK2

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:93,184,139-93,320,569 (from NCBI)

This gene has 15 transcripts (splice variants), 333 orthologues, 6 paralogues and is associated with 88 phenotypes. Broad expression in heart (RPKM 6.5), colon (RPKM 6.3) and 18 other tissues.

功能概要

该基因编码的蛋白质是属于蛋白激酶超家族的细胞质丝氨酸-苏氨酸激酶。该蛋白在调节电解质稳态、细胞信号转导存活和增殖中起着重要作用。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 9 月]

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

WNK2 基因产物(2)

mRNA Protein Name
NM_001282394.3 NP_001269323.1 serine/threonine-protein kinase WNK2 isoform 1
NM_006648.4 NP_006639.3 serine/threonine-protein kinase WNK2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
35044719 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in monoatomic ion homeostasis IMP
IMP: 通过突变表型推断
21733846 GOA
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
17667937 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
17667937 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
23797875 GOA
involved in positive regulation of sodium ion transmembrane transporter activity IMP
IMP: 通过突变表型推断
21733846 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
17667937 GOA
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
21733846 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17667937 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

WNK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (200 - 453)

OSR1_C

OSR1_C: Oxidative-stress-responsive kinase 1 C-terminal domain (474 - 511)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2297 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase WNK2

antigen NY-CO-43

关联疾病

疾病名称 别名
Hypomagnesemia 4, Renal

Renal Hypomagnesemia 4

HOMG4

Hypomagnesemia, Renal, Normocalciuric

Hypomagnesemia 4

Renal Hypomagnesemia Normocalciuric

Hypomagnesemia, Type 4, Renal
Suprasellar Meningioma
Angiomatous Meningioma
Pseudohypoaldosteronism
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100626 WNK463 Inhibitor 99.75% 否
HY-RS15824 WNK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus WNK2 RGD RGD:1307284
Canis familiaris WNK2 VGNC VGNC:54853
Mus musculus WNK2 MGD MGI:1922857
Macaca mulatta WNK2 VGNC VGNC:78961
Bos taurus WNK2 VGNC VGNC:36950
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