1. Gene
  2. SLC11A1 - solute carrier family 11 member 1 Gene

SLC11A1 - solute carrier family 11 member 1 Gene

中文名称:溶质载体家族 11 成员 1

种属: Homo sapiens

同用名: LSH; NRAMP; NRAMP1

基因 ID: 6556 | 基因类型: protein coding

关于 SLC11A1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,382,273-218,396,894 (from NCBI)

This gene has 18 transcripts (splice variants), 131 orthologues, 1 paralogue and is associated with 4 phenotypes. Biased expression in lung (RPKM 10.4), appendix (RPKM 8.8) and 7 other tissues.

功能概要

该基因是溶质载体家族 11 (质子偶联二价金属离子转运蛋白) 家族的成员,编码多通道膜蛋白。该蛋白质作为一种二价过渡金属 (铁和锰) 转运蛋白,参与铁代谢和宿主对某些病原体的抵抗力。该基因的突变与结核病和麻风病等传染病以及类风湿性关节炎和克罗恩病等炎症性疾病的易感性有关。已经描述了编码不同蛋白质同种型的可变剪接变体,但仅确定了一个的全长性质。[RefSeq 提供,2008 年 7 月]

This gene is a member of the solute carrier family 11 (proton-coupled divalent metal ion transporters) family and encodes a multi-pass membrane protein. The protein functions as a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Mutations in this gene have been associated with susceptibility to infectious diseases such as tuberculosis and leprosy, and inflammatory diseases such as rheumatoid arthritis and Crohn disease. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

SLC11A1 基因产物(1)

mRNA Protein Name
NM_000578.4 NP_000569.3 natural resistance-associated macrophage protein 1

SLC11A1 蛋白结构

Nramp

Nramp: Natural resistance-associated macrophage protein (78 - 462)

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蛋白主名 其他名称

natural resistance-associated macrophage protein 1

Leishmaniasis resistance

关联疾病

疾病名称 别名
Buruli Ulcer

Buruli Ulcer, Susceptibility To

Buruli Ulcer Disease

Mycobacterium Ulcerans

Mycobacterium Ulcerans, Susceptibility To

Bairnsdale Ulcer

Daintree Ulcer

Mossman Ulcer

Searl Ulcer

Searle'S Ulcer

Bud

Typhoid Fever

Typhoid

Enteric Fever

Typhoidal Salmonellosis

Ileotyphus

Infection By Salmonella Typhi

Typhoid Any Site

Typhoid Fever Any Site

Typhoid Infection

Typhoid Infection Any Site

Typhoid Fever Confirmed

Enteric Fever Nos

Leishmaniasis

Post-Kala-Azar Dermal Leishmaniasis

Post Kala-Azar Dermal Leishmaniasis

Post-Kala-Azar Dermal Infectious Disease By Leishmaniasis

Cutaneous Leishmaniasis

Kala-Azar

Visceral Leishmaniasis

Leishmaniasis, Cutaneous

Leishmaniasis, Visceral

Leishmania

Leishmania Infection

Leishmaniosis

Mycobacterium Tuberculosis 1

Tuberculosis

Tuberculoma

Tuberculosis, Susceptibility To

Mycobacterium Tuberculosis, Susceptibility To, 1

Mtbs1

TB

Pulmonary Tuberculosis

Tuberculosis, Pulmonary

PTB

Tuberculosis Pulmonary

Tularemia

Francisella Tularensis Infection

Deerfly Fever

Lemming Fever

Ohara Disease

Pahvant Valley Plague

Rabbit Fever

Yatobyo

Disease By Infectious Agent

Infectious Disease

Infectious Diseases

Visceral Leishmaniasis

Kala-Azar

Leishmaniasis, Visceral

Infection By Visceral Leishmaniasis

Leishmaniasis Visceral

Sahib Disease

Ponos

Burdwan Fever

Mard El Bicha

Sirkari Disease

Indian Visceral Leishmaniasis

Dumdum Fever

Visceral Leishmaniasis Due To Leishmania Donovani

Brucellosis

Mediterranean Fever

Malta Fever

Undulant Fever

Gibraltar Fever

Bang'S Disease

Maltese Fever

Cyprus Fever

Rock Fever

Brucellosis Infection

Brucella Infection

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Q Fever

Infection Due To Coxiella Burnetii

Quadrilateral Fever

Query Fever

Nine Mile Fever

Coxiella Burnetii Fever

Q Fever Pneumonia

Coxiellosis

Pneumonia In Q Fever

Australian Q Fever

Balkan Grippe

Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis

Juvenile Rheumatoid Arthritis

Juvenile Idiopathic Arthritis

Juvenile Chronic Polyarthritis

Monarticular Juvenile Rheumatoid Arthritis

Pauciarticular Juvenile Arthritis

Still'S Disease

Systemic Juvenile Rheumatoid Arthritis

Juvenile Chronic Arthritis

Acute Juvenile Rheumatoid Arthritis

Pauciarticular Onset Juvenile Chronic Arthritis

Arthritis, Juvenile Rheumatoid

Jia

Jra

Juvenile Ra

Arthritis Juvenile Rheumatoid

Stills Disease

Juvenile Arthritis

Acute Polyarticular Juvenile Rheumatoid Arthritis

Pauciarticular Juvenile Rheumatoid Arthritis

Rheumatoid Arthritis, Systemic Juvenile

Septicemic Plague

Plague, Septicemic

Lymphadenitis

Acute Lymphadenitis

Chronic Lymphadenitis

Adenitis

Chronic Adenitis

Acute Adenitis

Inflammation Of Lymph Node

Adenitis Nos

Inflammation Of Gland

Lymphatic Gland Inflammation

Lymph Gland Inflammation

Polyadenitis

Chronic Adenitis Of Any Lymph Node Except Mesenteric

Chronic Lymphadenitis Except Mesenteric

Chronic Non-Specific Lymphadenitis

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Type 1 Diabetes Mellitus 7

Diabetes Mellitus, Insulin-Dependent, 7

Iddm7

Insulin-Dependent Diabetes Mellitus 7

T1D7

Salmonellosis

Salmonella Infections

Salmonella Infection

Macs Syndrome

Macrocephaly, Alopecia, Cutis Laxa, And Scoliosis

Mycobacterium Avium Complex Disease

Rin2 Syndrome

Mycobacterium Avium-Intracellulare Infection

Tall Forehead, Sparse Hair, Skin Hyperextensibility, And Scoliosis

Mycobacterium Avium Complex

Mycobacterium Avium Infection

Infection Due To Mycobacterium Intracellulare

Mac Disease

Macrocephaly-Alopecia-Cutis Laxa-Scoliosis Syndrome

Rin2 Deficiency

Tall Forehead-Sparse Hair-Skin Hyperextensibility-Scoliosis Syndrome

MACS

Macrocephaly Alopecia Cutis Laxa And Scoliosis Syndrome

Leprosy 3

Leprosy

Leprosy, Susceptibility To, 3

Hansen'S Disease

Leprosy, Susceptibility To

Hansen Disease

Infection Due To Mycobacterium Leprae

LPRS3

Leprosy, Type 3

Anaesthesia Leprosy

Anaesthetic Leprosy

Maculoanaesthetic Leprosy

Macular Leprosy

Leprosy Unspecified

Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease

Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia

Iron Metabolism Disease

Iron Deficiency

Iron Disorder

Iron Metabolism Disorders

Disorder Of Iron Metabolism

Iron

Fe Deficiency

Iron Storage Disease

Iron Storage Disorder

Type 1 Diabetes Mellitus 17

Diabetes Mellitus, Insulin-Dependent, 17

Iddm17

Insulin-Dependent Diabetes Mellitus 17

TID17

Insulin-Dependent Diabetes Mellitus-17

Gastrointestinal Tularemia

Enteric Tularemia

Intestinal Tularaemia

Primary Bacterial Infectious Disease
Laryngeal Tuberculosis

Tuberculosis, Laryngeal

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Sarcoidosis 1

Sarcoidosis

Boeck Sarcoid

Besnier-Boeck-Schaumann Disease

SS1

Sarcoidosis, Susceptibility To, 1

Lymphogranulomatosis

Hodgkin Disease

Boeck'S Disease

Boeck'S Sarcoid

Schaumann'S Disease Or Syndrome

Hutchinson-Boeck Disease Or Syndrome

Urogenital Tuberculosis

Tuberculosis, Urogenital

Genitourinary Tuberculosis

Lung Disease

Lung Diseases

Disorder Of Lung

Abnormality Of The Lung

Borderline Leprosy

Midborderline Leprosy

Borderline Or Dimorphous Leprosy

Leprosy, Borderline

Tuberculoid Leprosy

Smooth Leprosy

Type T Leprosy

Leprosy Tuberculoid

Leprosy, Tuberculoid

Indeterminate Leprosy

Uncharacteristic Leprosy

Bacterial Infectious Disease

Bacterial Infections

Bacterial Infection Nos

Disease Caused By Bacteria

Bacterial Disease Or Disorder

Lepromatous Leprosy

Leprosy, Lepromatous

Type L Leprosy

Leprosy Lepromatous

Splenic Disease

Splenic Diseases

Dyssplenism

Spleen Disease

Abnormality Of The Spleen

Spleen Diseases

Microcytic Anemia

Iron-Refractory Iron Deficiency Anemia

Extrapulmonary Tuberculosis

EPTB

Tuberculosis, Extrapulmonary

Mucocutaneous Leishmaniasis

American Cutaneous Leishmaniasis

American Mucocutaneous Leishmaniasis

Cutaneous Leishmaniasis, American

Mucocutaneous Leishmaniasis, American

New World Cutaneous Leishmaniasis

Leishmaniasis, Mucocutaneous

Espundia

Leishmania Braziliensis Infection

Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SLC11A1 RGD RGD:1601463
Bos taurus SLC11A1 VGNC VGNC:34663
Felis catus SLC11A1 VGNC VGNC:65186
Macaca mulatta SLC11A1 VGNC VGNC:77382
Canis familiaris SLC11A1 VGNC VGNC:46216
Mus musculus SLC11A1 MGD MGI:1345275
Others SLC11A1 NCBI