2. Gene
  3. STK33 - serine/threonine kinase 33 Gene

STK33 - serine/threonine kinase 33 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丝氨酸/苏氨酸激酶 33

种属: Homo sapiens

基因 ID: 65975 | 基因类型: protein coding

关于 STK33

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:8,334,824-8,594,228 (from NCBI)

This gene has 18 transcripts (splice variants), 189 orthologues and 22 paralogues. Biased expression in testis (RPKM 7.0), thyroid (RPKM 2.1) and 11 other tissues.

功能概要

预测启用蛋白质丝氨酸/苏氨酸激酶活性。预计参与有丝分裂 DNA 损伤检查点信号和蛋白质自磷酸化。预测位于细胞质的核周区。预计在细胞质和细胞核中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in mitotic DNA damage checkpoint signaling and protein autophosphorylation. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

STK33 基因产物(17)

mRNA Protein Name
NM_001289058.2 NP_001275987.1 serine/threonine-protein kinase 33 isoform b
NM_001289059.2 NP_001275988.1 serine/threonine-protein kinase 33 isoform c
NM_001289061.2 NP_001275990.1 serine/threonine-protein kinase 33 isoform a
NM_001352387.2 NP_001339316.1 serine/threonine-protein kinase 33 isoform a
NM_001352388.2 NP_001339317.1 serine/threonine-protein kinase 33 isoform a
NM_001352389.2 NP_001339318.1 serine/threonine-protein kinase 33 isoform a
NM_001352390.2 NP_001339319.1 serine/threonine-protein kinase 33 isoform a
NM_001352391.2 NP_001339320.1 serine/threonine-protein kinase 33 isoform a
NM_001352392.2 NP_001339321.1 serine/threonine-protein kinase 33 isoform a
NM_001352393.2 NP_001339322.1 serine/threonine-protein kinase 33 isoform a
NM_001352394.2 NP_001339323.1 serine/threonine-protein kinase 33 isoform b
NM_001352395.2 NP_001339324.1 serine/threonine-protein kinase 33 isoform b
NM_001352396.2 NP_001339325.1 serine/threonine-protein kinase 33 isoform d
NM_001352397.2 NP_001339326.1 serine/threonine-protein kinase 33 isoform d
NM_001352398.2 NP_001339327.1 serine/threonine-protein kinase 33 isoform d
NM_001352399.2 NP_001339328.1 serine/threonine-protein kinase 33 isoform e
NM_030906.4 NP_112168.1 serine/threonine-protein kinase 33 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
37146716 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in spermatogenesis IMP
IMP: 通过突变表型推断
37146716 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

STK33 蛋白结构

Pkinase

Pkinase: Protein kinase domain (116 - 381)

  • 0
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  • 514 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase 33

关联疾病

疾病名称 别名
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Tyrosinemia, Type Iii

Tyrosinemia Type Iii

4-Hydroxyphenylpyruvate Dioxygenase Deficiency

TYRSN3

4-Hydroxyphenylpyruvic Acid Oxidase Deficiency

Tyrosinemia Type 3

4-Alpha Hydroxyphenylpyruvate Dioxygenase Deficiency

4-Alpha Hydroxyphenylpyruvic Acid Oxidase Deficiency

Tyrosinemia Due To 4-Hydroxyphenylpyruvate Dioxygenase Deficiency

Tyrosinemia Due To 4-Hydroxyphenylpyruvic Acid Oxidase Deficiency

Tyrosinemia Due To Hpd Deficiency

Tyrosinemia 3
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13495 ML281 Inhibitor 99.91% 否
HY-13497 STK33-IN-1 Inhibitor / 否
HY-13498 BRD-8899 Inhibitor / 否
HY-162565 CDD-2807 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus STK33 RGD RGD:1590972
Felis catus STK33 VGNC VGNC:65783
Bos taurus STK33 VGNC VGNC:35396
Macaca mulatta STK33 VGNC VGNC:78118
Mus musculus STK33 MGD MGI:2152419
Canis familiaris STK33 VGNC VGNC:46916
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