2. Gene
  3. DLK2 - delta like non-canonical Notch ligand 2 Gene

DLK2 - delta like non-canonical Notch ligand 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：三角洲样非典型 Notch 配体 2

种属: Homo sapiens

同用名: DLK-2; EGFL9

基因 ID: 65989 | 基因类型: protein coding

关于 DLK2

This gene has 4 transcripts (splice variants), 201 orthologues and 8 paralogues. Broad expression in skin (RPKM 1.9), prostate (RPKM 1.6) and 23 other tissues.

功能概要

预测启用 Notch 绑定活动。参与 Notch 信号通路的负调控。预计是膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable Notch binding activity. Involved in negative regulation of Notch signaling pathway. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

DLK2 基因产物(4)

mRNA Protein Name
NM_001286655.1 NP_001273584.1 protein delta homolog 2 isoform b precursor
NM_001286656.2 NP_001273585.1 protein delta homolog 2 isoform c precursor
NM_023932.4 NP_076421.2 protein delta homolog 2 isoform a precursor
NM_206539.2 NP_996262.1 protein delta homolog 2 isoform a precursor
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
25093684 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DLK2 蛋白结构

hEGF

hEGF: Human growth factor-like EGF (45 - 57)

EGF

EGF: EGF-like domain (95 - 126)

hEGF

hEGF: Human growth factor-like EGF (159 - 171)

EGF

EGF: EGF-like domain (178 - 207)

EGF

EGF: EGF-like domain (216 - 246)

  • 0
  • 100
  • 200
  • 300
  • 383 a.a.
蛋白主名 其他名称

protein delta homolog 2

EGF-like protein 9

关联疾病

疾病名称 别名
Spinal Muscular Atrophy, X-Linked 2

SMAX2

Arthrogryposis Multiplex Congenita, Distal, X-Linked

Infantile-Onset X-Linked Spinal Muscular Atrophy

Xlsma

Amcx1

Spinal Muscular Atrophy, X-Linked Lethal Infantile

Spinal Muscular Atrophy, Infantile X-Linked

Amc, Distal, X-Linked

Spinal Muscular Atrophy, X-Linked 2, Infantile

X-Linked Spinal Muscular Atrophy 2

Spinal Muscular Atrophy With Arthrogryposis

X-Linked Distal Arthrogryposis Multiplex Congenita

X-Linked Spinal Muscular Atrophy Type 2

Xl-Sma

Arthrogryposis, X-Linked, Type I

Spinal Muscular Atrophy, X-Linked Infantile

X-Linked Infantile Spinal Muscular Atrophy

Arthrogryposis, X-Lined, Type I

Distal X-Linked Amc

Infantile X-Linked Sma

X-Linked Arthrogryposis Multiplex Congenita

X-Linked Arthrogryposis Type I

X-Linked Lethal Infantile Sma

Arthrogryposis Spinal Muscular Atrophy

Spinal Muscular Atrophy X-Linked 2

Amc Distal X-Linked

Arthrogryposis Multiplex Congenita Distal X-Linked

Arthrogryposis X-Linked Type I

Spinal Muscular Atrophy Infantile X-Linked

Spinal Muscular Atrophy X-Linked Lethal Infantile

Atrophy, Muscular, Spinal, X-Linked, Type 2, Infantile
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03807 DLK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DLK2 VGNC VGNC:39985
Bos taurus DLK2 VGNC VGNC:28093
Mus musculus DLK2 MGD MGI:2146838
Felis catus DLK2 VGNC VGNC:61518
Rattus norvegicus DLK2 RGD RGD:1309143
Others DLK2 NCBI
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